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10.1038/s41598-018-23510-3 http://scihub22266oqcxt.onion/10.1038/s41598-018-23510-3 C5865214!5865214!29572462     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29572462.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2018 ; 8 (ä): ä Nephropedia Template TP {{tp|p=29572462|t=2018. Regulation of IL-22BP in psoriasis |pdf=|usr=}}{{29572462}} gab.com Text Regulation of IL-22BP in psoriasis JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29572462 #FOAvip IL-22 is a potent pro-inflammatory cytokine upregulated in psoriasis and in other inflammatory diseases. The function of IL-22 is regulated by the soluble scavenging receptor, IL-22 binding protein (IL-22BP or IL-22RA2). However, the role and regulation of IL-22BP itself in the pathogenesis of inflammatory disease remain unclear. We used the TLR7 agonist Imiquimod (IMQ) to induce a psoriasis-like skin disease in mice and found a strong downregulation of IL-22BP in the affected skin as well as in the lymph nodes of animals treated with IMQ. We also analysed psoriatic skin of patients and compared this to skin of healthy donors. Interestingly, IL-22BP expression was similarly downregulated in skin biopsies of psoriasis patients compared to the skin of healthy donors. Since IL-22BP is expressed foremost in dendritic cells, we characterized its expression in monocyte-derived dendritic cells (MoDC) during maturation. In this way, we found Prostaglandin E2 (PGE2) to be a potent suppressor of IL-22BP expression in vitro. We conclude that regulation of IL-22BP by inflammatory mediators is an important step for the progression of inflammation in the skin and possibly also in other autoimmune diseases. Twit Text FOAVip Regulation of IL-22BP in psoriasis ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29572462 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29572462 #FOAvip English Wikipedia <ref>{{Cite pmid|29572462}}</ref> Regulation of IL-22BP in psoriasis #MMPMID29572462 Voglis S; Moos S; Kloos L; Wanke F; Zayoud M; Pelczar P; Giannou AD; Pezer S; Albers M; Luessi F; Huber S; Schäkel K; Kurschus FC Sci Rep 2018[]; 8 (ä): ä PMID29572462show ga IL-22 is a potent pro-inflammatory cytokine upregulated in psoriasis and in other inflammatory diseases. The function of IL-22 is regulated by the soluble scavenging receptor, IL-22 binding protein (IL-22BP or IL-22RA2). However, the role and regulation of IL-22BP itself in the pathogenesis of inflammatory disease remain unclear. We used the TLR7 agonist Imiquimod (IMQ) to induce a psoriasis-like skin disease in mice and found a strong downregulation of IL-22BP in the affected skin as well as in the lymph nodes of animals treated with IMQ. We also analysed psoriatic skin of patients and compared this to skin of healthy donors. Interestingly, IL-22BP expression was similarly downregulated in skin biopsies of psoriasis patients compared to the skin of healthy donors. Since IL-22BP is expressed foremost in dendritic cells, we characterized its expression in monocyte-derived dendritic cells (MoDC) during maturation. In this way, we found Prostaglandin E2 (PGE2) to be a potent suppressor of IL-22BP expression in vitro. We conclude that regulation of IL-22BP by inflammatory mediators is an important step for the progression of inflammation in the skin and possibly also in other autoimmune diseases. äRegulation of IL-22BP in psoriasis (epmc).pdf DeepDyve Pubget Overpricing