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10.3892/ol.2017.6700 http://scihub22266oqcxt.onion/10.3892/ol.2017.6700 C5604125!5604125!28943897     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28943897.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncol+Lett 2017 ; 14 (4): 3883-92 Nephropedia Template TP {{tp|p=28943897|t=2017. Role of liver ICAM-1 in metastasis |pdf=|usr=}}{{28943897}} gab.com Text Role of liver ICAM-1 in metastasis JO: Oncol Lett http://www.kidney.de/pget.php?&tw=1&pmid=28943897 #FOAvip Intercellular adhesion molecule (ICAM)-1, is a transmembrane glycoprotein of the immunoglobulin (Ig)-like superfamily, consisting of five extracellular Ig-like domains, a transmembrane domain and a short cytoplasmic tail. ICAM-1 is expressed in various cell types, including endothelial cells and leukocytes, and is involved in several physiological processes. Furthermore, it has additionally been reported to be expressed in various cancer cells, including melanoma, colorectal cancer and lymphoma. The majority of studies to date have focused on the expression of the ICAM-1 on the surface of tumor cells, without research into ICAM-1 expression at sites of metastasis. Cancer cells frequently metastasize to the liver, due to its unique physiology and specialized liver sinusoid capillary network. Liver sinusoidal endothelial cells constitutively express ICAM-1, which is upregulated under inflammatory conditions. Furthermore, liver ICAM-1 may be important during the development of liver metastasis. Therefore, it is necessary to improve the understanding of the mechanisms mediated by this adhesion molecule in order to develop host-directed anticancer therapies. Twit Text FOAVip Role of liver ICAM-1 in metastasis ????Oncol Lett http://www.kidney.de/pget.php?&tw=1&pmid=28943897 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28943897 #FOAvip English Wikipedia <ref>{{Cite pmid|28943897}}</ref> Role of liver ICAM-1 in metastasis #MMPMID28943897 Benedicto A; Romayor I; Arteta B Oncol Lett 2017[Oct]; 14 (4): 3883-92 PMID28943897show ga Intercellular adhesion molecule (ICAM)-1, is a transmembrane glycoprotein of the immunoglobulin (Ig)-like superfamily, consisting of five extracellular Ig-like domains, a transmembrane domain and a short cytoplasmic tail. ICAM-1 is expressed in various cell types, including endothelial cells and leukocytes, and is involved in several physiological processes. Furthermore, it has additionally been reported to be expressed in various cancer cells, including melanoma, colorectal cancer and lymphoma. The majority of studies to date have focused on the expression of the ICAM-1 on the surface of tumor cells, without research into ICAM-1 expression at sites of metastasis. Cancer cells frequently metastasize to the liver, due to its unique physiology and specialized liver sinusoid capillary network. Liver sinusoidal endothelial cells constitutively express ICAM-1, which is upregulated under inflammatory conditions. Furthermore, liver ICAM-1 may be important during the development of liver metastasis. Therefore, it is necessary to improve the understanding of the mechanisms mediated by this adhesion molecule in order to develop host-directed anticancer therapies. äRole of liver ICAM-1 in metastasis (epmc).pdf DeepDyve Pubget Overpricing