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10.1016/j.bbadis.2014.05.035

http://scihub22266oqcxt.onion/10.1016/j.bbadis.2014.05.035
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C4257896!4257896!24907564
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suck abstract from ncbi


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pmid24907564      Biochim+Biophys+Acta 2014 ; 1842 (ä): 2555-60
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  • Role of soluble adenylyl cyclase in mitochondria #MMPMID24907564
  • Valsecchi F; Konrad C; Manfredi G
  • Biochim Biophys Acta 2014[Dec]; 1842 (ä): 2555-60 PMID24907564show ga
  • The soluble adenylyl cyclase (sAC) catalyzes the conversion of ATP into cyclic AMP (cAMP). Recent studies have shed new light on the role of sAC localized in mitochondria and its product cAMP, which drives mitochondrial protein phosphorylation and regulation of the oxidative phosphorylation system and other metabolic enzymes, presumably through the activation of intra-mitochondrial PKA. In this review article, we summarize recent findings on mitochondrial sAC activation by bicarbonate (HCO3?) and calcium (Ca2+) and the effects on mitochondrial metabolism. We also discuss putative mechanisms whereby sAC-mediated mitochondrial protein phosphorylation regulates mitochondrial metabolism.
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