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10.1155/2015/205054 http://scihub22266oqcxt.onion/10.1155/2015/205054 C4644547!4644547!26609197     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26609197.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mediators+Inflamm 2015 ; 2015 (�): � Nephropedia Template TP {{tp|p=26609197|t=2015. Sepsis and ARDS: The Dark Side of Histones |pdf=|usr=}}{{26609197}} gab.com Text Sepsis and ARDS: The Dark Side of Histones JO: Mediators Inflamm http://www.kidney.de/pget.php?&tw=1&pmid=26609197 #FOAvip Despite advances in management over the last several decades, sepsis and acute respiratory distress syndrome (ARDS) still remain major clinical challenges and the leading causes of death for patients in intensive care units (ICUs) due to insufficient understanding of the pathophysiological mechanisms of these diseases. However, recent studies have shown that histones, also known as chromatin-basic structure proteins, could be released into the extracellular space during severe stress and physical challenges to the body (e.g., sepsis and ARDS). Due to their cytotoxic and proinflammatory effects, extracellular histones can lead to excessive and overwhelming cell damage and death, thus contributing to the pathogenesis of both sepsis and ARDS. In addition, antihistone-based treatments (e.g., neutralizing antibodies, activated protein C, and heparin) have shown protective effects and have significantly improved the outcomes of mice suffering from sepsis and ARDS. Here, we review researches related to the pathological role of histone in context of sepsis and ARDS and evaluate the potential value of histones as biomarkers and therapeutic targets of these diseases. Twit Text FOAVip Sepsis and ARDS: The Dark Side of Histones ????Mediators Inflamm http://www.kidney.de/pget.php?&tw=1&pmid=26609197 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26609197 #FOAvip English Wikipedia <ref>{{Cite pmid|26609197}}</ref> Sepsis and ARDS: The Dark Side of Histones #MMPMID26609197 Xu Z; Huang Y; Mao P; Zhang J; Li Y Mediators Inflamm 2015[]; 2015 (�): � PMID26609197show ga Despite advances in management over the last several decades, sepsis and acute respiratory distress syndrome (ARDS) still remain major clinical challenges and the leading causes of death for patients in intensive care units (ICUs) due to insufficient understanding of the pathophysiological mechanisms of these diseases. However, recent studies have shown that histones, also known as chromatin-basic structure proteins, could be released into the extracellular space during severe stress and physical challenges to the body (e.g., sepsis and ARDS). Due to their cytotoxic and proinflammatory effects, extracellular histones can lead to excessive and overwhelming cell damage and death, thus contributing to the pathogenesis of both sepsis and ARDS. In addition, antihistone-based treatments (e.g., neutralizing antibodies, activated protein C, and heparin) have shown protective effects and have significantly improved the outcomes of mice suffering from sepsis and ARDS. Here, we review researches related to the pathological role of histone in context of sepsis and ARDS and evaluate the potential value of histones as biomarkers and therapeutic targets of these diseases. �Sepsis and ARDS: The Dark Side of Histones (epmc).pdf DeepDyve Pubget Overpricing