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10.1534/genetics.117.300521 http://scihub22266oqcxt.onion/10.1534/genetics.117.300521 C5887131!5887131!29618588     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29618588.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Genetics 2018 ; 208 (4): 1279-89 Nephropedia Template TP {{tp|p=29618588|t=2018. Sleep-Active Neurons: Conserved Motors of Sleep |pdf=|usr=}}{{29618588}} gab.com Text Sleep-Active Neurons: Conserved Motors of Sleep JO: Genetics http://www.kidney.de/pget.php?&tw=1&pmid=29618588 #FOAvip Sleep is crucial for survival and well-being. This behavioral and physiological state has been studied in all major genetically accessible model animals, including rodents, fish, flies, and worms. Genetic and optogenetic studies have identified several neurons that control sleep, making it now possible to compare circuit mechanisms across species. The ?motor? of sleep across animal species is formed by neurons that depolarize at the onset of sleep to actively induce this state by directly inhibiting wakefulness. These sleep-inducing neurons are themselves controlled by inhibitory or activating upstream pathways, which act as the ?drivers? of the sleep motor: arousal inhibits ?sleep-active? neurons whereas various sleep-promoting ?tiredness? pathways converge onto sleep-active neurons to depolarize them. This review provides the first overview of sleep-active neurons across the major model animals. The occurrence of sleep-active neurons and their regulation by upstream pathways in both vertebrate and invertebrate species suggests that these neurons are general and ancient components that evolved early in the history of nervous systems. Twit Text FOAVip Sleep-Active Neurons: Conserved Motors of Sleep ????Genetics http://www.kidney.de/pget.php?&tw=1&pmid=29618588 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29618588 #FOAvip English Wikipedia <ref>{{Cite pmid|29618588}}</ref> Sleep-Active Neurons: Conserved Motors of Sleep #MMPMID29618588 Bringmann H Genetics 2018[Apr]; 208 (4): 1279-89 PMID29618588show ga Sleep is crucial for survival and well-being. This behavioral and physiological state has been studied in all major genetically accessible model animals, including rodents, fish, flies, and worms. Genetic and optogenetic studies have identified several neurons that control sleep, making it now possible to compare circuit mechanisms across species. The ?motor? of sleep across animal species is formed by neurons that depolarize at the onset of sleep to actively induce this state by directly inhibiting wakefulness. These sleep-inducing neurons are themselves controlled by inhibitory or activating upstream pathways, which act as the ?drivers? of the sleep motor: arousal inhibits ?sleep-active? neurons whereas various sleep-promoting ?tiredness? pathways converge onto sleep-active neurons to depolarize them. This review provides the first overview of sleep-active neurons across the major model animals. The occurrence of sleep-active neurons and their regulation by upstream pathways in both vertebrate and invertebrate species suggests that these neurons are general and ancient components that evolved early in the history of nervous systems. äSleep-Active Neurons: Conserved Motors of Sleep (epmc).pdf DeepDyve Pubget Overpricing