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10.1126/science.1159689 http://scihub22266oqcxt.onion/10.1126/science.1159689 C5898235!5898235!18703739     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\18703739.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Science 2008 ; 321 (5891): 960-4 Nephropedia Template TP {{tp|p=18703739|t=2008. Small CRISPR RNAs Guide Antiviral Defense in Prokaryotes |pdf=|usr=}}{{18703739}} gab.com Text Small CRISPR RNAs Guide Antiviral Defense in Prokaryotes JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=18703739 #FOAvip Prokaryotes acquire virus resistance by integrating short fragments of viral nucleic acid into clusters of regularly interspaced short palindromic repeats (CRISPRs). Here we show how virus-derived sequences contained in CRISPRs are used by CRISPR-associated (Cas) proteins from the host to mediate an antiviral response that counteracts infection. After transcription of the CRISPR, a complex of Cas proteins termed Cascade cleaves a CRISPR RNA precursor in each repeat and retains the cleavage products containing the virus-derived sequence. Assisted by the helicase Cas3, these mature CRISPR RNAs then serve as small guide RNAs that enable Cascade to interfere with virus proliferation. Our results demonstrate that the formation of mature guide RNAs by the CRISPR RNA endonuclease subunit of Cascade is a mechanistic requirement for antiviral defense. Twit Text FOAVip Small CRISPR RNAs Guide Antiviral Defense in Prokaryotes ????Science http://www.kidney.de/pget.php?&tw=1&pmid=18703739 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=18703739 #FOAvip English Wikipedia <ref>{{Cite pmid|18703739}}</ref> Small CRISPR RNAs Guide Antiviral Defense in Prokaryotes #MMPMID18703739 Brouns SJJ; Jore MM; Lundgren M; Westra ER; Slijkhuis RJH; Snijders APL; Dickman MJ; Makarova KS; Koonin EV; van der Oost J Science 2008[Aug]; 321 (5891): 960-4 PMID18703739show ga Prokaryotes acquire virus resistance by integrating short fragments of viral nucleic acid into clusters of regularly interspaced short palindromic repeats (CRISPRs). Here we show how virus-derived sequences contained in CRISPRs are used by CRISPR-associated (Cas) proteins from the host to mediate an antiviral response that counteracts infection. After transcription of the CRISPR, a complex of Cas proteins termed Cascade cleaves a CRISPR RNA precursor in each repeat and retains the cleavage products containing the virus-derived sequence. Assisted by the helicase Cas3, these mature CRISPR RNAs then serve as small guide RNAs that enable Cascade to interfere with virus proliferation. Our results demonstrate that the formation of mature guide RNAs by the CRISPR RNA endonuclease subunit of Cascade is a mechanistic requirement for antiviral defense. äSmall CRISPR RNAs Guide Antiviral Defense in Prokaryotes (epmc).pdf DeepDyve Pubget Overpricing