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Syndrome in question: antisynthetase syndrome (anti-PL-7)* #MMPMID27828653
Esposito ACC; Gige TC; Miot HA
An Bras Dermatol 2016[Sep]; 91 (5): 683-5 PMID27828653show ga
Antisynthetase syndrome is a rare autoimmune disease characterized by interstitial lung disease and/or inflammatory myositis, with positive antisynthetase antibodies (anti-Jo-1, anti-PL-7, anti-PL-12, ZO, OJ, anti-KE or KS). Other symptoms described include: non-erosive arthritis, fever, Raynaud's phenomenon, and "mechanic's hands." The first therapeutic option is corticotherapy, followed by other immunosuppressants. The prognosis of the disease is quite limited when compared to other inflammatory myopathies with negative antisynthetase antibodies.