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10.1146/annurev-pharmtox-010715-103507 http://scihub22266oqcxt.onion/10.1146/annurev-pharmtox-010715-103507 C5586045!5586045!27732798     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27732798.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Annu+Rev+Pharmacol+Toxicol 2017 ; 57 (�): 107-23 Nephropedia Template TP {{tp|p=27732798|t=2017. Targeted Protein Degradation by Small Molecules |pdf=|usr=}}{{27732798}} gab.com Text Targeted Protein Degradation by Small Molecules JO: Annu Rev Pharmacol Toxicol http://www.kidney.de/pget.php?&tw=1&pmid=27732798 #FOAvip Protein homeostasis networks are highly regulated systems responsible for maintaining the health and productivity of cells. Whereas therapeutics have been developed to disrupt protein homeostasis, more recently identified techniques have been used to repurpose homeostatic networks to effect degradation of disease-relevant proteins. Here, we review recent advances in the use of small molecules to degrade proteins in a selective manner. First, we highlight all-small-molecule techniques with direct clinical application. Second, we describe techniques that may find broader acceptance in the biomedical research community that require little or no synthetic chemistry. In addition to serving as innovative research tools, these new approaches to control intracellular protein levels offer the potential to develop novel therapeutics targeting proteins that are not currently pharmaceutically vulnerable. Twit Text FOAVip Targeted Protein Degradation by Small Molecules ????Annu Rev Pharmacol Toxicol http://www.kidney.de/pget.php?&tw=1&pmid=27732798 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27732798 #FOAvip English Wikipedia <ref>{{Cite pmid|27732798}}</ref> Targeted Protein Degradation by Small Molecules #MMPMID27732798 Bondeson DP; Crews CM Annu Rev Pharmacol Toxicol 2017[Jan]; 57 (�): 107-23 PMID27732798show ga Protein homeostasis networks are highly regulated systems responsible for maintaining the health and productivity of cells. Whereas therapeutics have been developed to disrupt protein homeostasis, more recently identified techniques have been used to repurpose homeostatic networks to effect degradation of disease-relevant proteins. Here, we review recent advances in the use of small molecules to degrade proteins in a selective manner. First, we highlight all-small-molecule techniques with direct clinical application. Second, we describe techniques that may find broader acceptance in the biomedical research community that require little or no synthetic chemistry. In addition to serving as innovative research tools, these new approaches to control intracellular protein levels offer the potential to develop novel therapeutics targeting proteins that are not currently pharmaceutically vulnerable. �Targeted Protein Degradation by Small Molecules (epmc).pdf DeepDyve Pubget Overpricing