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10.14348/molcells.2018.2297 http://scihub22266oqcxt.onion/10.14348/molcells.2018.2297 C6030247!6030247!29754476     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29754476.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mol+Cells 2018 ; 41 (6): 506-14 Nephropedia Template TP {{tp|p=29754476|t=2018. Targeting Super-Enhancers for Disease Treatment and Diagnosis |pdf=|usr=}}{{29754476}} gab.com Text Targeting Super-Enhancers for Disease Treatment and Diagnosis JO: Mol Cells http://www.kidney.de/pget.php?&tw=1&pmid=29754476 #FOAvip The transcriptional regulation of genes determines the fate of animal cell differentiation and subsequent organ development. With the recent progress in genome-wide technologies, the genomic landscapes of enhancers have been broadly explored in mammalian genomes, which led to the discovery of novel specific subsets of enhancers, termed super-enhancers. Super-enhancers are large clusters of enhancers covering the long region of regulatory DNA and are densely occupied by transcription factors, active histone marks, and co-activators. Accumulating evidence points to the critical role that super-enhancers play in cell type-specific development and differentiation, as well as in the development of various diseases. Here, I provide a comprehensive description of the optimal approach for identifying functional units of super-enhancers and their unique chromatin features in normal development and in diseases, including cancers. I also review the recent updated knowledge on novel approaches of targeting super-enhancers for the treatment of specific diseases, such as small-molecule inhibitors and potential gene therapy. This review will provide perspectives on using super-enhancers as biomarkers to develop novel disease diagnostic tools and establish new directions in clinical therapeutic strategies. Twit Text FOAVip Targeting Super-Enhancers for Disease Treatment and Diagnosis ????Mol Cells http://www.kidney.de/pget.php?&tw=1&pmid=29754476 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29754476 #FOAvip English Wikipedia <ref>{{Cite pmid|29754476}}</ref> Targeting Super-Enhancers for Disease Treatment and Diagnosis #MMPMID29754476 Shin HY Mol Cells 2018[Jun]; 41 (6): 506-14 PMID29754476show ga The transcriptional regulation of genes determines the fate of animal cell differentiation and subsequent organ development. With the recent progress in genome-wide technologies, the genomic landscapes of enhancers have been broadly explored in mammalian genomes, which led to the discovery of novel specific subsets of enhancers, termed super-enhancers. Super-enhancers are large clusters of enhancers covering the long region of regulatory DNA and are densely occupied by transcription factors, active histone marks, and co-activators. Accumulating evidence points to the critical role that super-enhancers play in cell type-specific development and differentiation, as well as in the development of various diseases. Here, I provide a comprehensive description of the optimal approach for identifying functional units of super-enhancers and their unique chromatin features in normal development and in diseases, including cancers. I also review the recent updated knowledge on novel approaches of targeting super-enhancers for the treatment of specific diseases, such as small-molecule inhibitors and potential gene therapy. This review will provide perspectives on using super-enhancers as biomarkers to develop novel disease diagnostic tools and establish new directions in clinical therapeutic strategies. äTargeting Super-Enhancers for Disease Treatment and Diagnosis (epmc).pdf DeepDyve Pubget Overpricing