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10.1534/genetics.115.184101 http://scihub22266oqcxt.onion/10.1534/genetics.115.184101 C4827730!4827730!26883445     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26883445&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26883445.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Genetics 2016 ; 202 (4): 1549-61 Nephropedia Template TP {{tp|p=26883445|t=2016. The Site Frequency Spectrum for General Coalescents |pdf=|usr=}}{{26883445}} gab.com Text The Site Frequency Spectrum for General Coalescents JO: Genetics http://www.kidney.de/pget.php?&tw=1&pmid=26883445 #FOAvip General genealogical processes such as ?- and ?-coalescents, which respectively model multiple and simultaneous mergers, have important applications in studying marine species, strong positive selection, recurrent selective sweeps, strong bottlenecks, large sample sizes, and so on. Recently, there has been significant progress in developing useful inference tools for such general models. In particular, inference methods based on the site frequency spectrum (SFS) have received noticeable attention. Here, we derive a new formula for the expected SFS for general ?- and ?-coalescents, which leads to an efficient algorithm. For time-homogeneous coalescents, the runtime of our algorithm for computing the expected SFS is O(n2), where n is the sample size. This is a factor of n2 faster than the state-of-the-art method. Furthermore, in contrast to existing methods, our method generalizes to time-inhomogeneous ?- and ?-coalescents with measures that factorize as ?(dx)/?(t) and ?(dx)/?(t), respectively, where ? denotes a strictly positive function of time. The runtime of our algorithm in this setting is O(n3). We also obtain general theoretical results for the identifiability of the ? measure when ? is a constant function, as well as for the identifiability of the function ? under a fixed ? measure. Twit Text FOAVip The Site Frequency Spectrum for General Coalescents ????Genetics http://www.kidney.de/pget.php?&tw=1&pmid=26883445 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26883445 #FOAvip English Wikipedia <ref>{{Cite pmid|26883445}}</ref> The Site Frequency Spectrum for General Coalescents #MMPMID26883445 Spence JP; Kamm JA; Song YS Genetics 2016[Apr]; 202 (4): 1549-61 PMID26883445show ga General genealogical processes such as ?- and ?-coalescents, which respectively model multiple and simultaneous mergers, have important applications in studying marine species, strong positive selection, recurrent selective sweeps, strong bottlenecks, large sample sizes, and so on. Recently, there has been significant progress in developing useful inference tools for such general models. In particular, inference methods based on the site frequency spectrum (SFS) have received noticeable attention. Here, we derive a new formula for the expected SFS for general ?- and ?-coalescents, which leads to an efficient algorithm. For time-homogeneous coalescents, the runtime of our algorithm for computing the expected SFS is O(n2), where n is the sample size. This is a factor of n2 faster than the state-of-the-art method. Furthermore, in contrast to existing methods, our method generalizes to time-inhomogeneous ?- and ?-coalescents with measures that factorize as ?(dx)/?(t) and ?(dx)/?(t), respectively, where ? denotes a strictly positive function of time. The runtime of our algorithm in this setting is O(n3). We also obtain general theoretical results for the identifiability of the ? measure when ? is a constant function, as well as for the identifiability of the function ? under a fixed ? measure. äThe Site Frequency Spectrum for General Coalescents (epmc).pdf DeepDyve Pubget Overpricing