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10.1002/jcb.25736 http://scihub22266oqcxt.onion/10.1002/jcb.25736 C5558502!5558502!27632380     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27632380.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Cell+Biochem 2017 ; 118 (4): 764-74 Nephropedia Template TP {{tp|p=27632380|t=2017. The Ultrastructural Signature of Human Embryonic Stem Cells |pdf=|usr=}}{{27632380}} gab.com Text The Ultrastructural Signature of Human Embryonic Stem Cells JO: J Cell Biochem http://www.kidney.de/pget.php?&tw=1&pmid=27632380 #FOAvip The epigenetics and molecular biology of human embryonic stem cells (hES cells) have received much more attention than their architecture. We present a more complete look at hES cells by electron microscopy, with a special emphasis on the architecture of the nucleus. We propose that there is an ultrastructural signature of pluripotent human cells. hES cell nuclei lack heterochromatin, including the peripheral heterochromatin, that is common in most somatic cell types. The absence of peripheral heterochromatin may be related to the absence of lamins A and C, proteins important for linking chromatin to the nuclear lamina and envelope. Lamin A and C expression and the development of peripheral heterochromatin were early steps in the development of embryoid bodies. While hES cell nuclei had abundant nuclear pores, they also had an abundance of nuclear pores in the cytoplasm in the form of annulate lamellae. These were not a residue of annulate lamellae from germ cells or the early embryos from which hES cells were derived. Subnuclear structures including nucleoli, interchromatin granule clusters, and Cajal bodies were observed in the nuclear interior. The architectural organization of human ES cell nuclei has important implications for cell structure ? gene expression relationships and for the maintenance of pluripotency. Twit Text FOAVip The Ultrastructural Signature of Human Embryonic Stem Cells ????J Cell Biochem http://www.kidney.de/pget.php?&tw=1&pmid=27632380 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27632380 #FOAvip English Wikipedia <ref>{{Cite pmid|27632380}}</ref> The Ultrastructural Signature of Human Embryonic Stem Cells #MMPMID27632380 Underwood JM; Becker K; Stein GS; Nickerson JA J Cell Biochem 2017[Apr]; 118 (4): 764-74 PMID27632380show ga The epigenetics and molecular biology of human embryonic stem cells (hES cells) have received much more attention than their architecture. We present a more complete look at hES cells by electron microscopy, with a special emphasis on the architecture of the nucleus. We propose that there is an ultrastructural signature of pluripotent human cells. hES cell nuclei lack heterochromatin, including the peripheral heterochromatin, that is common in most somatic cell types. The absence of peripheral heterochromatin may be related to the absence of lamins A and C, proteins important for linking chromatin to the nuclear lamina and envelope. Lamin A and C expression and the development of peripheral heterochromatin were early steps in the development of embryoid bodies. While hES cell nuclei had abundant nuclear pores, they also had an abundance of nuclear pores in the cytoplasm in the form of annulate lamellae. These were not a residue of annulate lamellae from germ cells or the early embryos from which hES cells were derived. Subnuclear structures including nucleoli, interchromatin granule clusters, and Cajal bodies were observed in the nuclear interior. The architectural organization of human ES cell nuclei has important implications for cell structure ? gene expression relationships and for the maintenance of pluripotency. �The Ultrastructural Signature of Human Embryonic Stem Cells (epmc).pdf DeepDyve Pubget Overpricing