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10.1038/nature21382 http://scihub22266oqcxt.onion/10.1038/nature21382 C5616216!5616216!28241138     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28241138&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28241138.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nature 2017 ; 543 (7644): 261-4 Nephropedia Template TP {{tp|p=28241138|t=2017. The molecular architecture of lamins in somatic cells |pdf=|usr=}}{{28241138}} gab.com Text The molecular architecture of lamins in somatic cells JO: Nature http://www.kidney.de/pget.php?&tw=1&pmid=28241138 #FOAvip The nuclear lamina is a fundamental constituent of metazoan nuclei. It is composed mainly of lamins, which are intermediate filament proteins that assemble into a filamentous meshwork, bridging the nuclear envelope and chromatin 1?4. Besides providing structural stability to the nucleus 5,6, the lamina is involved in many nuclear activities, including chromatin organization, transcription and replication 7?10. However, the structural organization of the nuclear lamina is poorly understood. Here, we use cryo-electron tomography (cryo-ET) to obtain a detailed view of the organization of the lamin meshwork within the lamina. Data analysis of individual lamin filaments resolves a globular-decorated fiber appearance and shows that A- and B-type lamins assemble into tetrameric 3.5 nm thick filaments. Thus, lamins exhibit a structure that is remarkably different from the other canonical cytoskeletal elements. Our findings define the architecture of the nuclear lamin meshworks at molecular resolution, providing insights into their role in scaffolding the nuclear lamina. Twit Text FOAVip The molecular architecture of lamins in somatic cells ????Nature http://www.kidney.de/pget.php?&tw=1&pmid=28241138 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28241138 #FOAvip English Wikipedia <ref>{{Cite pmid|28241138}}</ref> The molecular architecture of lamins in somatic cells #MMPMID28241138 Turgay Y; Eibauer M; Goldman AE; Shimi T; Khayat M; Ben-Harush K; Dubrovsky-Gaupp A; Sapra KT; Goldman RD; Medalia O Nature 2017[Mar]; 543 (7644): 261-4 PMID28241138show ga The nuclear lamina is a fundamental constituent of metazoan nuclei. It is composed mainly of lamins, which are intermediate filament proteins that assemble into a filamentous meshwork, bridging the nuclear envelope and chromatin 1?4. Besides providing structural stability to the nucleus 5,6, the lamina is involved in many nuclear activities, including chromatin organization, transcription and replication 7?10. However, the structural organization of the nuclear lamina is poorly understood. Here, we use cryo-electron tomography (cryo-ET) to obtain a detailed view of the organization of the lamin meshwork within the lamina. Data analysis of individual lamin filaments resolves a globular-decorated fiber appearance and shows that A- and B-type lamins assemble into tetrameric 3.5 nm thick filaments. Thus, lamins exhibit a structure that is remarkably different from the other canonical cytoskeletal elements. Our findings define the architecture of the nuclear lamin meshworks at molecular resolution, providing insights into their role in scaffolding the nuclear lamina. äThe molecular architecture of lamins in somatic cells (epmc).pdf DeepDyve Pubget Overpricing