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10.1259/bjr.20130738

http://scihub22266oqcxt.onion/10.1259/bjr.20130738
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C4453133!4453133!25009948
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suck abstract from ncbi


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pmid25009948      Br+J+Radiol 2014 ; 87 (1041): ä
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  • The role of inflammation in contrast-induced nephropathy #MMPMID25009948
  • Kwasa EA; Vinayak S; Armstrong R
  • Br J Radiol 2014[Sep]; 87 (1041): ä PMID25009948show ga
  • Objective:: Global incidence of contrast-induced nephropathy (CIN) is 2?5%, but a recent Kenyan study highlighted a local incidence of 12?14% without offering an explanation for the higher incidence. This study proposes that inflammatory states confer a higher relative risk for development of CIN. Our objective was to determine the risk of developing CIN given the presence of an inflammatory state in patients in Kenya. Methods:: Prospective cohort study of patients undergoing a contrast-enhanced CT (CECT) scan in a private university teaching hospital in Kenya and having no known risk factors for CIN. 423 patients were recruited and grouped into those without inflammation (unexposed) having serum C-reactive protein (CRP) levels ?5?mg?dl?1 and those with evidence of inflammation having CRP levels >5?mg?dl?1. Serum creatinine (SCr) was measured before the CECT and 48?h following the CECT with CIN diagnosed by an increase of >25% in the SCr from the baseline. Relative risk was determined and multiple logistic regression analysis performed on biophysical variables and contrast volume to assess their effect on development of CIN. Results:: Patients with high CRP levels had a relative risk of developing CIN of 2.16 compared with those with normal levels of CRP (p?=?0.016). No statistically significant association was seen between biophysical variables or volume of contrast and development of CIN. Conclusion:: Ongoing inflammation doubles the likelihood of development of CIN. Advances in knowledge:: This study highlights the importance of inflammation as a risk factor in the development of CIN.
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