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10.1016/j.addr.2014.07.003 http://scihub22266oqcxt.onion/10.1016/j.addr.2014.07.003 C4426864!4426864!25034878     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25034878.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Adv+Drug+Deliv+Rev 2014 ; ä (ä): 184-92 Nephropedia Template TP {{tp|p=25034878|t=2014. Three-dimensional modeling of ovarian cancer |pdf=|usr=}}{{25034878}} gab.com Text Three-dimensional modeling of ovarian cancer JO: Adv Drug Deliv Rev http://www.kidney.de/pget.php?&tw=1&pmid=25034878 #FOAvip New models for epithelial ovarian cancer initiation and metastasis are required to obtain a mechanistic understanding of the disease and to develop new therapeutics. Modeling ovarian cancer however is challenging as a result of the genetic heterogeneity of the malignancy, the diverse pathology, the limited availability of human tissue for research, the atypical mechanisms of metastasis, and because the origin is unclear. Insights into the origin of high-grade serous ovarian carcinomas and mechanisms of metastasis have resulted in the generation of novel three-dimensional (3D) culture models that better approximate the behavior of the tumor cells in vivo than prior two-dimensional models. The 3D models aim to recapitulate the tumor microenvironment, which has a critical role in the pathogenesis of ovarian cancer. Ultimately, findings using models that accurately reflect human ovarian cancer biology are likely to translate into improved clinical outcomes. In this review we discuss the design of new 3D culture models of ovarian cancer primarily using human cells, key studies in which these models have been applied, current limitations, and future applications. Twit Text FOAVip Three-dimensional modeling of ovarian cancer ????Adv Drug Deliv Rev http://www.kidney.de/pget.php?&tw=1&pmid=25034878 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25034878 #FOAvip English Wikipedia <ref>{{Cite pmid|25034878}}</ref> Three-dimensional modeling of ovarian cancer #MMPMID25034878 Erin W; Hilary K; Ernst L Adv Drug Deliv Rev 2014[Dec]; ä (ä): 184-92 PMID25034878show ga New models for epithelial ovarian cancer initiation and metastasis are required to obtain a mechanistic understanding of the disease and to develop new therapeutics. Modeling ovarian cancer however is challenging as a result of the genetic heterogeneity of the malignancy, the diverse pathology, the limited availability of human tissue for research, the atypical mechanisms of metastasis, and because the origin is unclear. Insights into the origin of high-grade serous ovarian carcinomas and mechanisms of metastasis have resulted in the generation of novel three-dimensional (3D) culture models that better approximate the behavior of the tumor cells in vivo than prior two-dimensional models. The 3D models aim to recapitulate the tumor microenvironment, which has a critical role in the pathogenesis of ovarian cancer. Ultimately, findings using models that accurately reflect human ovarian cancer biology are likely to translate into improved clinical outcomes. In this review we discuss the design of new 3D culture models of ovarian cancer primarily using human cells, key studies in which these models have been applied, current limitations, and future applications. äThree-dimensional modeling of ovarian cancer (epmc).pdf DeepDyve Pubget Overpricing