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10.1002/eji.201243192 http://scihub22266oqcxt.onion/10.1002/eji.201243192 C3774955!3774955!23616226     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=23616226&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\23616226.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Eur+J+Immunol 2013 ; 43 (6): 1425-9 Nephropedia Template TP {{tp|p=23616226|t=2013. Thymus-homing dendritic cells in central tolerance |pdf=|usr=}}{{23616226}} gab.com Text Thymus-homing dendritic cells in central tolerance JO: Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=23616226 #FOAvip Central tolerance is critical in establishing a peripheral T-cell repertoire purged of functional autoreactive T cells. One of the major requirements for effective central tolerance is the presentation of self and other innocuous antigens (Ags), including food, gut flora or airway allergens, to developing T cells in the thymus. This seemingly challenging task can be mediated in some cases by ectopic expression of tissue-specific Ags by thymic epithelial cells, or by entry of systemic blood borne Ags into the thymus. More recently, thymic homing peripheral dendritic cells (DCs) have been proposed as cellular transporters of peripheral tissue-specific Ags or foreign innocuous Ags. The aim of this viewpoint is to discuss the three principal thymic DC populations and their trafficking properties in the context of central tolerance. We will first discuss the importance of peripheral DC trafficking to the thymus and then compare and contrast the three DC subsets. We will describe how they were characterized; describe their trafficking to and their microenvironmental positioning in the thymus; and discuss the functional consequence of thymic trafficking and localization on thymic selection events. Twit Text FOAVip Thymus-homing dendritic cells in central tolerance ????Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=23616226 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23616226 #FOAvip English Wikipedia <ref>{{Cite pmid|23616226}}</ref> Thymus-homing dendritic cells in central tolerance #MMPMID23616226 Hadeiba H; Butcher EC Eur J Immunol 2013[Jun]; 43 (6): 1425-9 PMID23616226show ga Central tolerance is critical in establishing a peripheral T-cell repertoire purged of functional autoreactive T cells. One of the major requirements for effective central tolerance is the presentation of self and other innocuous antigens (Ags), including food, gut flora or airway allergens, to developing T cells in the thymus. This seemingly challenging task can be mediated in some cases by ectopic expression of tissue-specific Ags by thymic epithelial cells, or by entry of systemic blood borne Ags into the thymus. More recently, thymic homing peripheral dendritic cells (DCs) have been proposed as cellular transporters of peripheral tissue-specific Ags or foreign innocuous Ags. The aim of this viewpoint is to discuss the three principal thymic DC populations and their trafficking properties in the context of central tolerance. We will first discuss the importance of peripheral DC trafficking to the thymus and then compare and contrast the three DC subsets. We will describe how they were characterized; describe their trafficking to and their microenvironmental positioning in the thymus; and discuss the functional consequence of thymic trafficking and localization on thymic selection events. äThymus-homing dendritic cells in central tolerance (epmc).pdf DeepDyve Pubget Overpricing