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10.1007/82_2017_62

http://scihub22266oqcxt.onion/10.1007/82_2017_62
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C5902028!5902028!28900677
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suck abstract from ncbi


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pmid28900677      Curr+Top+Microbiol+Immunol 2017 ; 410 (ä): 127-56
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  • Tim-3, Lag-3, and TIGIT #MMPMID28900677
  • Joller N; Kuchroo VK
  • Curr Top Microbiol Immunol 2017[]; 410 (ä): 127-56 PMID28900677show ga
  • Co-inhibitory receptors play a key role in regulating T cell responses and maintaining immune homeostasis. Their inhibitory function prevents autoimmune responses but also restricts the ability of T cells to mount effective immune responses against tumors or persistent pathogens. T cells express a module of co-inhibitory receptors, which display great diversity in expression, structure, and function. Here, we focus on the co-inhibitory receptors Tim-3, Lag-3, and TIGIT and how they regulate T cell function, maintenance of self-tolerance, their role in regulating ongoing T cell responses at peripheral tissues, and their synergistic effects in regulating autoimmunity and antitumor responses.
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