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10.1038/emm.2017.313 http://scihub22266oqcxt.onion/10.1038/emm.2017.313 C5898904!5898904!29520112     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29520112.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Exp+Mol+Med 2018 ; 50 (3): e456- Nephropedia Template TP {{tp|p=29520112|t=2018. Transcriptional regulation and development of regulatory T cells |pdf=|usr=}}{{29520112}} gab.com Text Transcriptional regulation and development of regulatory T cells JO: Exp Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=29520112 #FOAvip Regulatory T (Treg) cells are a distinct subset of CD4+ T cells. Instead of triggering adaptive immunity, they suppress immune responses. Small numbers of Treg cells reside within lymphoid organs and peripheral tissues, but their contribution to immune tolerance is so significant that defects in Treg cell function cause catastrophic immune disorders. Since they were first discovered 20 years ago, efforts have been made to understand the differences in developmental processes between Treg cells and conventional T cells that determine the ultimate fate of the overall T-cell population. Transcription factor Foxp3 is crucial for Treg cell differentiation, but it is not the whole story. Owing to recent advances in Treg cell research, we are now on the verge of appreciating the comprehensive mechanisms underlying Treg cell generation. Here, we discuss major discoveries, active study topics and remaining questions regarding Treg cell development. Twit Text FOAVip Transcriptional regulation and development of regulatory T cells ????Exp Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=29520112 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29520112 #FOAvip English Wikipedia <ref>{{Cite pmid|29520112}}</ref> Transcriptional regulation and development of regulatory T cells #MMPMID29520112 Lee W; Lee GR Exp Mol Med 2018[Mar]; 50 (3): e456- PMID29520112show ga Regulatory T (Treg) cells are a distinct subset of CD4+ T cells. Instead of triggering adaptive immunity, they suppress immune responses. Small numbers of Treg cells reside within lymphoid organs and peripheral tissues, but their contribution to immune tolerance is so significant that defects in Treg cell function cause catastrophic immune disorders. Since they were first discovered 20 years ago, efforts have been made to understand the differences in developmental processes between Treg cells and conventional T cells that determine the ultimate fate of the overall T-cell population. Transcription factor Foxp3 is crucial for Treg cell differentiation, but it is not the whole story. Owing to recent advances in Treg cell research, we are now on the verge of appreciating the comprehensive mechanisms underlying Treg cell generation. Here, we discuss major discoveries, active study topics and remaining questions regarding Treg cell development. äTranscriptional regulation and development of regulatory T cells (epmc).pdf DeepDyve Pubget Overpricing