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10.1016/j.immuni.2014.06.010 http://scihub22266oqcxt.onion/10.1016/j.immuni.2014.06.010 C4137410!4137410!25035953     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25035953.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Immunity 2014 ; 41 (1): 49-61 Nephropedia Template TP {{tp|p=25035953|t=2014. Tumor-associated macrophages: from mechanisms to therapy |pdf=|usr=}}{{25035953}} gab.com Text Tumor-associated macrophages: from mechanisms to therapy JO: Immunity http://www.kidney.de/pget.php?&tw=1&pmid=25035953 #FOAvip The tumor microenvironment is a complex ecology of cells that evolves with and provides support to tumor cells during the transition to malignancy. Among the innate and adaptive immune cells recruited to the tumor site, macrophages are particularly abundant and are present at all stages of tumor progression. Clinical studies and experimental mouse models indicate these macrophages generally play a pro-tumoral role. In the primary tumor, macrophage can stimulate angiogenesis and enhance tumor cell invasion, motility and intravasation. During metastasis, macrophages prime the pre-metastatic site and promote tumor cell extravasation, survival and persistent growth. Macrophages are also immunosuppressive preventing tumor cell attack by natural killer and T cells during tumor progression and after recovery from chemo- or immuno-therapy. Therapeutic success in targeting these pro-tumoral roles in pre-clinical models and in early clinical trials suggests that macrophages are attractive targets as part of combination therapy in cancer treatment. Twit Text FOAVip Tumor-associated macrophages: from mechanisms to therapy ????Immunity http://www.kidney.de/pget.php?&tw=1&pmid=25035953 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25035953 #FOAvip English Wikipedia <ref>{{Cite pmid|25035953}}</ref> Tumor-associated macrophages: from mechanisms to therapy #MMPMID25035953 Noy R; Pollard JW Immunity 2014[Jul]; 41 (1): 49-61 PMID25035953show ga The tumor microenvironment is a complex ecology of cells that evolves with and provides support to tumor cells during the transition to malignancy. Among the innate and adaptive immune cells recruited to the tumor site, macrophages are particularly abundant and are present at all stages of tumor progression. Clinical studies and experimental mouse models indicate these macrophages generally play a pro-tumoral role. In the primary tumor, macrophage can stimulate angiogenesis and enhance tumor cell invasion, motility and intravasation. During metastasis, macrophages prime the pre-metastatic site and promote tumor cell extravasation, survival and persistent growth. Macrophages are also immunosuppressive preventing tumor cell attack by natural killer and T cells during tumor progression and after recovery from chemo- or immuno-therapy. Therapeutic success in targeting these pro-tumoral roles in pre-clinical models and in early clinical trials suggests that macrophages are attractive targets as part of combination therapy in cancer treatment. äTumor-associated macrophages: from mechanisms to therapy (epmc).pdf DeepDyve Pubget Overpricing