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10.1080/19491034.2016.1190896 http://scihub22266oqcxt.onion/10.1080/19491034.2016.1190896 C4991243!4991243!27249516     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27249516&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27249516.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nucleus 2016 ; 7 (3): 319-24 Nephropedia Template TP {{tp|p=27249516|t=2016. Unraveling the mechanisms of chromatin fibril packaging |pdf=|usr=}}{{27249516}} gab.com Text Unraveling the mechanisms of chromatin fibril packaging JO: Nucleus http://www.kidney.de/pget.php?&tw=1&pmid=27249516 #FOAvip Recent data indicate that eukaryotic chromosomes are organized into Topologically Associating Domains (TADs); however, the mechanisms underlying TAD formation remain obscure. Based on the results of Hi-C analysis performed on 4 Drosophila melanogaster cell lines, we have proposed that specific properties of nucleosomes in active and repressed chromatin play a key role in the formation of TADs. Our computer simulations showed that the ability of ?inactive? nucleosomes to stick to each other and the lack of such ability in ?active? nucleosomes is sufficient for spatial segregation of these types of chromatin, which is revealed in the Hi-C analysis as TAD/inter-TAD partitioning. However, some Drosophila and mammalian TADs contain both active and inactive chromatin, a fact that does not fit this model. Herein, we present additional arguments for the model by postulating that transcriptionally active chromatin is extruded on the surface of a TAD, and discuss the possible impact of this organization on the enhancer-promoter communication and on the segregation of TADs. Twit Text FOAVip Unraveling the mechanisms of chromatin fibril packaging ????Nucleus http://www.kidney.de/pget.php?&tw=1&pmid=27249516 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27249516 #FOAvip English Wikipedia <ref>{{Cite pmid|27249516}}</ref> Unraveling the mechanisms of chromatin fibril packaging #MMPMID27249516 Gavrilov AA; Shevelyov YY; Ulianov SV; Khrameeva EE; Kos P; Chertovich A; Razin SV Nucleus 2016[]; 7 (3): 319-24 PMID27249516show ga Recent data indicate that eukaryotic chromosomes are organized into Topologically Associating Domains (TADs); however, the mechanisms underlying TAD formation remain obscure. Based on the results of Hi-C analysis performed on 4 Drosophila melanogaster cell lines, we have proposed that specific properties of nucleosomes in active and repressed chromatin play a key role in the formation of TADs. Our computer simulations showed that the ability of ?inactive? nucleosomes to stick to each other and the lack of such ability in ?active? nucleosomes is sufficient for spatial segregation of these types of chromatin, which is revealed in the Hi-C analysis as TAD/inter-TAD partitioning. However, some Drosophila and mammalian TADs contain both active and inactive chromatin, a fact that does not fit this model. Herein, we present additional arguments for the model by postulating that transcriptionally active chromatin is extruded on the surface of a TAD, and discuss the possible impact of this organization on the enhancer-promoter communication and on the segregation of TADs. �Unraveling the mechanisms of chromatin fibril packaging (epmc).pdf DeepDyve Pubget Overpricing