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Urinary tract infection in children: recurrent infections #MMPMID26067232
Larcombe J
BMJ Clin Evid 2015[]; 2015 (ä): ä PMID26067232show ga
Introduction: Up to 11% of girls and 7% of boys will have had a urinary tract infection (UTI) by the age of 16 years, and recurrence of infection is common. Vesicoureteric reflux (VUR) is identified in up to 40% of children being investigated for a first UTI, and is a risk factor for, but weak predictor of, renal parenchymal defects. Methods and outcomes: We conducted a systematic review and aimed to answer the following clinical questions: What are the effects of prophylactic antibiotics to prevent recurrent urinary tract infection in children? We searched: Medline, Embase, The Cochrane Library, and other important databases up to December 2013 (BMJ Clinical Evidence reviews are updated periodically; please check our website for the most up-to-date version of this review). Results: We found three studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions. Conclusions: In this systematic review we present information relating to the effectiveness and safety of the following intervention: prophylactic antibiotics.