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10.1186/s13045-017-0471-6

http://scihub22266oqcxt.onion/10.1186/s13045-017-0471-6
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C5420131!5420131!28476164
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suck abstract from ncbi


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pmid28476164      J+Hematol+Oncol 2017 ; 10 (ä): ä
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  • Wnt/beta-catenin pathway: modulating anticancer immune response #MMPMID28476164
  • Pai SG; Carneiro BA; Mota JM; Costa R; Leite CA; Barroso-Sousa R; Kaplan JB; Chae YK; Giles FJ
  • J Hematol Oncol 2017[]; 10 (ä): ä PMID28476164show ga
  • Wnt/?-catenin signaling, a highly conserved pathway through evolution, regulates key cellular functions including proliferation, differentiation, migration, genetic stability, apoptosis, and stem cell renewal. The Wnt pathway mediates biological processes by a canonical or noncanonical pathway, depending on the involvement of ?-catenin in signal transduction. ?-catenin is a core component of the cadherin protein complex, whose stabilization is essential for the activation of Wnt/?-catenin signaling. As multiple aberrations in this pathway occur in numerous cancers, WNT-directed therapy represents an area of significant developmental therapeutics focus. The recently described role of Wnt/?-catenin pathway in regulating immune cell infiltration of the tumor microenvironment renewed the interest, given its potential impact on responses to immunotherapy treatments. This article summarizes the role of Wnt/?-catenin pathway in cancer and ongoing therapeutic strategies involving this pathway.
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