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http://scihub22266oqcxt.onion/ 10535321!ä!10535321 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\10535321.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+J+Dev+Biol 1999 ; 43 (5): 441-3 Nephropedia Template TP {{tp|p=10535321|t=1999. Dopamine in the developing kidney |pdf=|usr=}}{{10535321}} gab.com Text Dopamine in the developing kidney JO: Int J Dev Biol http://www.kidney.de/pget.php?&tw=1&pmid=10535321 #FOAvip The adult kidney has a high rate of dopamine (DA) production, metabolism, and signalling. The non-neuronal DA system in the adult kidney is of utmost importance for the regulation of salt metabolism. DA may also act as a transcription factor and may be of importance for tissue differentiation. In the central nervous system, D1 receptors require the dopamine- and cAMP-regulated phosphoprotein with a molecular weight of 32,000 Dalton (DARPP-32) to mediate their actions. The renal D1 mediates DARPP-32 activation via a cascade involving cAMP and PKA, and protein kinase C (PKC) activation via phospholipase C. Active DARPP-32 has a specific inhibitory effect on protein phosphatase 1 (PP1), leaving, e.g. Na+,K+-ATPase in a phosphorylated, inactive, state. Thus, dopamine acts as a natriuretic hormone in the mature kidney. Here, we discuss the age-dependent distribution and some functional aspects of several parts of the renal dopamine system (dopamine, AADC, COMT, D1 receptor, and DARPP-32) during renal morphogenesis. Twit Text FOAVip Dopamine in the developing kidney ????Int J Dev Biol http://www.kidney.de/pget.php?&tw=1&pmid=10535321 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=10535321 #FOAvip English Wikipedia <ref>{{Cite pmid|10535321}}</ref> Dopamine in the developing kidney #MMPMID10535321 Svennilson J; Aperia A Int J Dev Biol 1999[]; 43 (5): 441-3 PMID10535321show ga The adult kidney has a high rate of dopamine (DA) production, metabolism, and signalling. The non-neuronal DA system in the adult kidney is of utmost importance for the regulation of salt metabolism. DA may also act as a transcription factor and may be of importance for tissue differentiation. In the central nervous system, D1 receptors require the dopamine- and cAMP-regulated phosphoprotein with a molecular weight of 32,000 Dalton (DARPP-32) to mediate their actions. The renal D1 mediates DARPP-32 activation via a cascade involving cAMP and PKA, and protein kinase C (PKC) activation via phospholipase C. Active DARPP-32 has a specific inhibitory effect on protein phosphatase 1 (PP1), leaving, e.g. Na+,K+-ATPase in a phosphorylated, inactive, state. Thus, dopamine acts as a natriuretic hormone in the mature kidney. Here, we discuss the age-dependent distribution and some functional aspects of several parts of the renal dopamine system (dopamine, AADC, COMT, D1 receptor, and DARPP-32) during renal morphogenesis. |*Nerve Tissue Proteins[MESH] |Animals[MESH] |Dopamine and cAMP-Regulated Phosphoprotein 32[MESH] |Dopamine/metabolism/*physiology[MESH] |Kidney/embryology/*growth & development/*metabolism[MESH] |Morphogenesis[MESH] |Phosphoproteins/metabolism[MESH]Dopamine in the developing kidney (epmc).pdf DeepDyve Pubget Overpricing