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Progressionsverlauf experimentell ausgeloster arteriosklerotischer Gefasswandveranderungen nach Behandlung mit Magnesiumorotat #MMPMID11190771
Jellinek H; Takacs E
Arzneimittelforschung 2000[Dec]; 50 (12): 1071-7 PMID11190771show ga
There are some experimental and clinical results regarding blood vessel protective properties of magnesium orotate (CAS 27067-77-2) till now. The goal of the present investigation was to verify the therapeutical efficacy of magnesium orotate vs. its singular components in cholesterol fed rabbits. Besides, the blood-lipid concentrations (LDL as risk factor for atherosclerosis and HDL as negative risk factor) were analyzed in relation to pathomorphological changes in the aortic blood vessel wall. The results of our experiments in New Zealand rabbits support the assumption that orotic acid and especially magnesium orotate influence the lipid level and/or the LDL/HDL-quotient in a favorable way and that they decrease the interaction between monocytes/macrophages and the endothelium of the blood vessels. Consequently, the plaque formation will be decreased in a clinically relevant manner.