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10.4049/jimmunol.166.12.7381 http://scihub22266oqcxt.onion/10.4049/jimmunol.166.12.7381 11390489!ä!11390489 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=11390489&cmd=llinks): Failed to open stream: HTTP request failed! 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Fc receptor-mediated phagocytosis makes a significant contribution to clearance of influenza virus infections |pdf=|usr=}}{{11390489}} gab.com Text Fc receptor-mediated phagocytosis makes a significant contribution to clearance of influenza virus infections JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=11390489 #FOAvip Fc receptors for IgG expressed on macrophages and NK cells are important mediators of opsonophagocytosis and Ab-dependent cell-mediated cytotoxicity. Phagocyte-mediated opsonophagocytosis is pivotal for protection against bacteria, but its importance in recovery from infection with intracellular pathogens is unclear. We have now investigated the role of opsonophagocytosis in protection against lethal influenza virus infection by using FcR gamma(-/-) mice. Absence of the FcR gamma-chain did not affect the expression of IFN-gamma and IL-10 in the lungs and spleens after intranasal immunization with an influenza subunit vaccine. Titers of serum and respiratory Abs of the IgM, IgG1, IgG2a, and IgA isotypes in FcR gamma(-/-) mice were similar to levels seen in FcR gamma(+/+) mice. Nevertheless, FcR gamma(-/-) mice were highly susceptible to influenza infection, even in the presence of anti-influenza Abs from immune FcR gamma(+/+) mice. NK cells were not necessary for the observed Ab-mediated viral clearance, but macrophages were found to be capable of actively ingesting opsonized virus particles. We conclude that Fc receptor-mediated phagocytosis plays a pivotal role in clearance of respiratory virus infections. Twit Text FOAVip Fc receptor-mediated phagocytosis makes a significant contribution to clearance of influenza virus infections ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=11390489 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=11390489 #FOAvip English Wikipedia <ref>{{Cite pmid|11390489}}</ref> Fc receptor-mediated phagocytosis makes a significant contribution to clearance of influenza virus infections #MMPMID11390489 Huber VC; Lynch JM; Bucher DJ; Le J; Metzger DW J Immunol 2001[Jun]; 166 (12): 7381-8 PMID11390489show ga Fc receptors for IgG expressed on macrophages and NK cells are important mediators of opsonophagocytosis and Ab-dependent cell-mediated cytotoxicity. Phagocyte-mediated opsonophagocytosis is pivotal for protection against bacteria, but its importance in recovery from infection with intracellular pathogens is unclear. We have now investigated the role of opsonophagocytosis in protection against lethal influenza virus infection by using FcR gamma(-/-) mice. Absence of the FcR gamma-chain did not affect the expression of IFN-gamma and IL-10 in the lungs and spleens after intranasal immunization with an influenza subunit vaccine. Titers of serum and respiratory Abs of the IgM, IgG1, IgG2a, and IgA isotypes in FcR gamma(-/-) mice were similar to levels seen in FcR gamma(+/+) mice. Nevertheless, FcR gamma(-/-) mice were highly susceptible to influenza infection, even in the presence of anti-influenza Abs from immune FcR gamma(+/+) mice. NK cells were not necessary for the observed Ab-mediated viral clearance, but macrophages were found to be capable of actively ingesting opsonized virus particles. We conclude that Fc receptor-mediated phagocytosis plays a pivotal role in clearance of respiratory virus infections. |*CD3 Complex[MESH] |Animals[MESH] |Antibodies, Viral/biosynthesis[MESH] |Cell Line[MESH] |Cytokines/biosynthesis[MESH] |Genetic Predisposition to Disease[MESH] |Humans[MESH] |Immune Sera/administration & dosage[MESH] |Immunization, Passive[MESH] |Immunoglobulin Isotypes/biosynthesis[MESH] |Influenza A virus/immunology[MESH] |Influenza, Human/genetics/*immunology/*prevention & control/virology[MESH] |Injections, Intraperitoneal[MESH] |Lung/immunology/metabolism[MESH] |Macrophages/immunology/virology[MESH] |Mice[MESH] |Mice, Inbred BALB C[MESH] |Mice, Inbred C57BL[MESH] |Mice, Inbred CBA[MESH] |Mice, Knockout[MESH] |Mice, Transgenic[MESH] |Phagocytosis/*immunology[MESH] |Receptors, Antigen, T-Cell/genetics[MESH] |Receptors, Fc/deficiency/genetics/*physiology[MESH]Fc receptor-mediated phagocytosis makes a significant contribution to (epmc).pdf DeepDyve Pubget Overpricing