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10.1006/viro.2001.1029 http://scihub22266oqcxt.onion/10.1006/viro.2001.1029 11504551!ä!11504551 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=11504551&cmd=llinks): Failed to open stream: HTTP request failed! 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Impaired microglial activation in the brain of IL-18-gene-disrupted mice after neurovirulent influenza A virus infection |pdf=|usr=}}{{11504551}} gab.com Text Impaired microglial activation in the brain of IL-18-gene-disrupted mice after neurovirulent influenza A virus infection JO: Virology http://www.kidney.de/pget.php?&tw=1&pmid=11504551 #FOAvip Knockout of the interleukin-18 (IL-18) gene predisposed mice to impaired clearance of neurovirulent influenza A virus-infected neurons from the brain. In wild-type mice, IL-18 molecule-producing microglia/macrophages emerged in virally attacked regions as early as day 3 after infection. Microglial transformation into macrophages culminated at day 7 to 9, with upregulated expression of Iba1, a novel calcium-binding protein that controls phagocytic functions of microglia/macrophages. In IL-18-/- mice, microglial transformation was interrupted with reduced Iba1 expression. Interferon-gamma (IFN-gamma)-immunopositive neurons appeared in and around virally invaded regions in wild-type mice, peaking in number at day 7, whereas such cells were barely detected in IL-18-/- mice. Stereotaxic microinjection of recombinant IFN-gamma triggered microglial transformation in IL-18-/- mice and upregulated Iba1 expression, leading to effective eradication of virally infected neurons. Collectively, these results suggest that IL-18 plays a key role in activating microglial functions directed against the influenza virus infection by inducing neuronal IFN-gamma in the brain parenchyma. Twit Text FOAVip Impaired microglial activation in the brain of IL-18-gene-disrupted mice after neurovirulent influenza A virus infection ????Virology http://www.kidney.de/pget.php?&tw=1&pmid=11504551 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=11504551 #FOAvip English Wikipedia <ref>{{Cite pmid|11504551}}</ref> Impaired microglial activation in the brain of IL-18-gene-disrupted mice after neurovirulent influenza A virus infection #MMPMID11504551 Mori I; Hossain MJ; Takeda K; Okamura H; Imai Y; Kohsaka S; Kimura Y Virology 2001[Aug]; 287 (1): 163-70 PMID11504551show ga Knockout of the interleukin-18 (IL-18) gene predisposed mice to impaired clearance of neurovirulent influenza A virus-infected neurons from the brain. In wild-type mice, IL-18 molecule-producing microglia/macrophages emerged in virally attacked regions as early as day 3 after infection. Microglial transformation into macrophages culminated at day 7 to 9, with upregulated expression of Iba1, a novel calcium-binding protein that controls phagocytic functions of microglia/macrophages. In IL-18-/- mice, microglial transformation was interrupted with reduced Iba1 expression. Interferon-gamma (IFN-gamma)-immunopositive neurons appeared in and around virally invaded regions in wild-type mice, peaking in number at day 7, whereas such cells were barely detected in IL-18-/- mice. Stereotaxic microinjection of recombinant IFN-gamma triggered microglial transformation in IL-18-/- mice and upregulated Iba1 expression, leading to effective eradication of virally infected neurons. Collectively, these results suggest that IL-18 plays a key role in activating microglial functions directed against the influenza virus infection by inducing neuronal IFN-gamma in the brain parenchyma. |*Influenza A virus[MESH] |Animals[MESH] |Brain/*physiopathology/virology[MESH] |Calcium-Binding Proteins/biosynthesis/genetics[MESH] |Female[MESH] |Interferon-gamma/pharmacology[MESH] |Interleukin-18/genetics/*physiology[MESH] |Macrophages/virology[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH] |Mice, Knockout[MESH] |Microfilament Proteins[MESH] |Microglia/*physiology/virology[MESH] |Microinjections[MESH] |Orthomyxoviridae Infections/*physiopathology[MESH] |Specific Pathogen-Free Organisms[MESH]Impaired microglial activation in the brain of IL-18-gene-disrupted mi(epmc).pdf DeepDyve Pubget Overpricing