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10.1099/0022-1317-83-9-2109 http://scihub22266oqcxt.onion/10.1099/0022-1317-83-9-2109 12185263!ä!12185263 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=12185263&cmd=llinks): Failed to open stream: HTTP request failed! 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Olfactory receptor neurons prevent dissemination of neurovirulent influenza A virus into the brain by undergoing virus-induced apoptosis |pdf=|usr=}}{{12185263}} gab.com Text Olfactory receptor neurons prevent dissemination of neurovirulent influenza A virus into the brain by undergoing virus-induced apoptosis JO: J Gen Virol http://www.kidney.de/pget.php?&tw=1&pmid=12185263 #FOAvip Olfactory receptor neurons (ORNs) were infected upon intranasal inoculation with the R404BP strain of neurovirulent influenza A virus. Virus-infected neurons and a small fraction of neighbouring uninfected neurons displayed apoptotic neurodegeneration substantiated by the immunohistochemistry for activated caspase-3 molecules and the terminal deoxynucleotidyl transferase-mediated dUTP nick end-labelling method. However, virus infection was restricted within the peripheral neuroepithelium and all mice survived the infection. Virus-infected ORNs revealed upregulated expression of the Fas ligand molecules, activating the c-Jun N-terminal kinase signal transduction pathway. In addition, Iba1-expressing activated microglia/macrophages appeared to partake in phagocytic activities, eventually clearing apoptotic bodies. These results raise the possibility that induction of apoptosis in olfactory receptor neurons at an early stage of infection may provide protective effects against invasion of the neurovirulent virus from the peripheral to the CNS. Twit Text FOAVip Olfactory receptor neurons prevent dissemination of neurovirulent influenza A virus into the brain by undergoing virus-induced apoptosis ????J Gen Virol http://www.kidney.de/pget.php?&tw=1&pmid=12185263 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=12185263 #FOAvip English Wikipedia <ref>{{Cite pmid|12185263}}</ref> Olfactory receptor neurons prevent dissemination of neurovirulent influenza A virus into the brain by undergoing virus-induced apoptosis #MMPMID12185263 Mori I; Goshima F; Imai Y; Kohsaka S; Sugiyama T; Yoshida T; Yokochi T; Nishiyama Y; Kimura Y J Gen Virol 2002[Sep]; 83 (Pt 9): 2109-2116 PMID12185263show ga Olfactory receptor neurons (ORNs) were infected upon intranasal inoculation with the R404BP strain of neurovirulent influenza A virus. Virus-infected neurons and a small fraction of neighbouring uninfected neurons displayed apoptotic neurodegeneration substantiated by the immunohistochemistry for activated caspase-3 molecules and the terminal deoxynucleotidyl transferase-mediated dUTP nick end-labelling method. However, virus infection was restricted within the peripheral neuroepithelium and all mice survived the infection. Virus-infected ORNs revealed upregulated expression of the Fas ligand molecules, activating the c-Jun N-terminal kinase signal transduction pathway. In addition, Iba1-expressing activated microglia/macrophages appeared to partake in phagocytic activities, eventually clearing apoptotic bodies. These results raise the possibility that induction of apoptosis in olfactory receptor neurons at an early stage of infection may provide protective effects against invasion of the neurovirulent virus from the peripheral to the CNS. |*Apoptosis[MESH] |*Influenza A virus/genetics[MESH] |*Nerve Degeneration[MESH] |Animals[MESH] |Brain/*virology[MESH] |Calcium-Binding Proteins/analysis/metabolism[MESH] |Central Nervous System Viral Diseases/*physiopathology/virology[MESH] |Fas Ligand Protein[MESH] |Female[MESH] |Membrane Glycoproteins/analysis/metabolism[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH] |Microfilament Proteins[MESH] |Microglia/metabolism[MESH] |Olfactory Mucosa/metabolism[MESH] |Olfactory Receptor Neurons/*physiopathology/virology[MESH] |Proto-Oncogene Proteins c-jun/analysis/metabolism[MESH] |Recombination, Genetic[MESH]Olfactory receptor neurons prevent dissemination of neurovirulent infl(epmc).pdf DeepDyve Pubget Overpricing