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10.1086/341947 http://scihub22266oqcxt.onion/10.1086/341947 12195370!�!12195370 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=12195370&cmd=llinks): Failed to open stream: HTTP request failed! 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Association of symptomatic acute human parvovirus B19 infection with human leukocyte antigen class I and II alleles |pdf=|usr=}}{{12195370}} gab.com Text Association of symptomatic acute human parvovirus B19 infection with human leukocyte antigen class I and II alleles JO: J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=12195370 #FOAvip To determine the effect of the major histocompatibility complex on the development of symptoms during acute human parvovirus B19 infection, we compared human leukocyte antigen (HLA) class I and II alleles in 36 patients with symptomatic acute B19 infection with those in >900 control subjects from northwestern England. The frequency of each of HLA-DRB1*01 (P=.016), DRB1*04 (P=.007), and DRB1*07 (P<.0001) alleles was significantly higher in parvovirus B19 patients than in control subjects. In the parvovirus group, 63.9% carried the rheumatoid arthritis-associated shared epitope sequence, compared with 45% of control subjects (odds ratio [OR], 2.2; 95% confidence interval [CI], 0.97-4.8; P=.04), and carriage was associated with fatigue during the acute phase (OR, 4.2; 95% CI, 0.8-23.9; P=.047). All symptomatic parvovirus-associated HLA-DRB1 molecules carry a neutrally charged glutamine at position 10 and a positively charged lysine at position 12 of the first hypervariable region. HLA-B49 was associated with parvovirus infection independently of HLA-DRB1*01, DRB1*04, and DRB1*07. Twit Text FOAVip Association of symptomatic acute human parvovirus B19 infection with human leukocyte antigen class I and II alleles ????J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=12195370 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=12195370 #FOAvip English Wikipedia <ref>{{Cite pmid|12195370}}</ref> Association of symptomatic acute human parvovirus B19 infection with human leukocyte antigen class I and II alleles #MMPMID12195370 Kerr JR; Mattey DL; Thomson W; Poulton KV; Ollier WE J Infect Dis 2002[Aug]; 186 (4): 447-52 PMID12195370show ga To determine the effect of the major histocompatibility complex on the development of symptoms during acute human parvovirus B19 infection, we compared human leukocyte antigen (HLA) class I and II alleles in 36 patients with symptomatic acute B19 infection with those in >900 control subjects from northwestern England. The frequency of each of HLA-DRB1*01 (P=.016), DRB1*04 (P=.007), and DRB1*07 (P<.0001) alleles was significantly higher in parvovirus B19 patients than in control subjects. In the parvovirus group, 63.9% carried the rheumatoid arthritis-associated shared epitope sequence, compared with 45% of control subjects (odds ratio [OR], 2.2; 95% confidence interval [CI], 0.97-4.8; P=.04), and carriage was associated with fatigue during the acute phase (OR, 4.2; 95% CI, 0.8-23.9; P=.047). All symptomatic parvovirus-associated HLA-DRB1 molecules carry a neutrally charged glutamine at position 10 and a positively charged lysine at position 12 of the first hypervariable region. HLA-B49 was associated with parvovirus infection independently of HLA-DRB1*01, DRB1*04, and DRB1*07. |*Genes, MHC Class I[MESH] |*Genes, MHC Class II[MESH] |*Parvovirus B19, Human[MESH] |Acute Disease[MESH] |Adolescent[MESH] |Adult[MESH] |Aged[MESH] |Alleles[MESH] |Amino Acid Sequence[MESH] |Child[MESH] |Female[MESH] |Gene Frequency[MESH] |HLA-B Antigens/genetics[MESH] |HLA-DR Antigens/genetics[MESH] |HLA-DRB1 Chains[MESH] |Humans[MESH] |Male[MESH] |Middle Aged[MESH] |Molecular Sequence Data[MESH]Association of symptomatic acute human parvovirus B19 infection with h(epmc).pdf DeepDyve Pubget Overpricing