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10.1111/j.1348-0421.1992.tb02110.x http://scihub22266oqcxt.onion/10.1111/j.1348-0421.1992.tb02110.x 1282653!ä!1282653 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\1282653.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Microbiol+Immunol 1992 ; 36 (10): 1061-75 Nephropedia Template TP {{tp|p=1282653|t=1992. Mechanisms of augmented resistance of cyclosporin A-treated mice to influenza virus infection by trehalose-6,6 -dimycolate |pdf=|usr=}}{{1282653}} gab.com Text Mechanisms of augmented resistance of cyclosporin A-treated mice to influenza virus infection by trehalose-6,6 -dimycolate JO: Microbiol Immunol http://www.kidney.de/pget.php?&tw=1&pmid=1282653 #FOAvip Cyclosporin A (CsA), which is an immunosuppressive drug of helper T lymphocytes, diminished a resistance of mice to influenza virus infection. Mice inoculated intravenously with trehalose-6,6'-dimycolate (TDM, a glycolipid component of the cell wall of Mycobacterium) in an oil-in-water emulsion (TDM emulsion) recovered the resistance to influenza virus infection impaired by CsA. Number of antibody-producing cells was markedly reduced in CsA- and/or TDM-treated mice. Interferon production in lung of TDM-treated mice was augmented; however, it was extremely reduced not only in CsA-treated mice, but also in CsA- and TDM-treated mice. Activities of natural killer cells of CsA- and/or TDM-treated mice were not different from that of control mice. Numbers of lymphocytes in lung of TDM-treated mice and CsA- and TDM-treated mice were more predominantly increased than that of control mice. Analysis of lung lymphocytes by flow cytometry revealed no difference between the populations of L3T4+ T lymphocytes and Lyt-2.2+ T lymphocytes in CsA- and/or TDM-treated mice and the populations in control mice. However, the population of gamma delta T cell receptor positive (gamma delta TCR+) lymphocytes increased markedly in lung of TDM-treated mice and also CsA- and TDM-treated mice. In vitro experiments showed that macrophage cultures treated with TDM emulsion released a mediator(s) which activates T lymphocytes, but not B lymphocytes. These and our earlier results suggest that the recovered anti-influenza virus resistance of CsA-treated mice by treatment with TDM emulsion was caused by elicitation of macrophages with TDM, then activation of T lymphocytes, especially gamma delta TCR+ lymphocytes. Twit Text FOAVip Mechanisms of augmented resistance of cyclosporin A-treated mice to influenza virus infection by trehalose-6,6 -dimycolate ????Microbiol Immunol http://www.kidney.de/pget.php?&tw=1&pmid=1282653 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=1282653 #FOAvip English Wikipedia <ref>{{Cite pmid|1282653}}</ref> Mechanisms of augmented resistance of cyclosporin A-treated mice to influenza virus infection by trehalose-6,6 -dimycolate #MMPMID1282653 Sazaki K; Yoshida I; Azuma M Microbiol Immunol 1992[]; 36 (10): 1061-75 PMID1282653show ga Cyclosporin A (CsA), which is an immunosuppressive drug of helper T lymphocytes, diminished a resistance of mice to influenza virus infection. Mice inoculated intravenously with trehalose-6,6'-dimycolate (TDM, a glycolipid component of the cell wall of Mycobacterium) in an oil-in-water emulsion (TDM emulsion) recovered the resistance to influenza virus infection impaired by CsA. Number of antibody-producing cells was markedly reduced in CsA- and/or TDM-treated mice. Interferon production in lung of TDM-treated mice was augmented; however, it was extremely reduced not only in CsA-treated mice, but also in CsA- and TDM-treated mice. Activities of natural killer cells of CsA- and/or TDM-treated mice were not different from that of control mice. Numbers of lymphocytes in lung of TDM-treated mice and CsA- and TDM-treated mice were more predominantly increased than that of control mice. Analysis of lung lymphocytes by flow cytometry revealed no difference between the populations of L3T4+ T lymphocytes and Lyt-2.2+ T lymphocytes in CsA- and/or TDM-treated mice and the populations in control mice. However, the population of gamma delta T cell receptor positive (gamma delta TCR+) lymphocytes increased markedly in lung of TDM-treated mice and also CsA- and TDM-treated mice. In vitro experiments showed that macrophage cultures treated with TDM emulsion released a mediator(s) which activates T lymphocytes, but not B lymphocytes. These and our earlier results suggest that the recovered anti-influenza virus resistance of CsA-treated mice by treatment with TDM emulsion was caused by elicitation of macrophages with TDM, then activation of T lymphocytes, especially gamma delta TCR+ lymphocytes. |Animals[MESH] |Antibodies, Viral/immunology[MESH] |Antibody-Producing Cells/immunology[MESH] |Cells, Cultured[MESH] |Cord Factors/*pharmacology[MESH] |Cyclosporine/*pharmacology[MESH] |Female[MESH] |Immunity, Innate/drug effects[MESH] |Influenza A virus/immunology[MESH] |Injections, Intravenous[MESH] |Interferons/biosynthesis[MESH] |Killer Cells, Natural/drug effects/immunology[MESH] |Lung/drug effects/immunology[MESH] |Lymphocyte Activation/drug effects[MESH] |Lymphocyte Subsets/drug effects/immunology[MESH] |Macrophages/drug effects/immunology[MESH] |Mice[MESH] |Mice, Inbred BALB C[MESH]Mechanisms of augmented resistance of cyclosporin A-treated mice to in(epmc).pdf DeepDyve Pubget Overpricing