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Effects of magnesium sulfate on neuron apoptosis and expression of caspase-3, bax and bcl-2 after cerebral ischemia-reperfusion injury |pdf=|usr=}}{{14570617}} gab.com Text Effects of magnesium sulfate on neuron apoptosis and expression of caspase-3, bax and bcl-2 after cerebral ischemia-reperfusion injury JO: Chin Med J (Engl) http://www.kidney.de/pget.php?&tw=1&pmid=14570617 #FOAvip OBJECTIVE: To investigate the effects of magnesium sulfate on neuron apoptosis and the expressions of caspase-3, bax and bcl-2 after cerebral ischemia-reperfusion injury. METHODS: Thirty-six gerbils were randomly divided into three groups: Sham-operation group (So, n = 12), ischemia-reperfusion group (I-R, n = 12) and magnesium sulfate group (Ms, n = 12). The neuron apoptosis was detected by the terminal deoxynucleotidyl transferase (TdT)-mediated dUTP-fluorescence nick end labeling (TUNEL stain), and the protein expressions of caspase-3, bax and bcl-2 were detected by immunohistochemisty stain. RESULTS: Apoptotic neurons and the expressions of caspase-3 and bax were significantly increased in I-R and Ms groups, compared with those in So group. Apoptotic neurons and the expressions of bax and caspase-3 in Ms group were significantly less than those in I-R group. There was no significant difference in the expression of bcl-2 among three groups. CONCLUSIONS: Magnesium sulfate decreases neuron apoptosis after cerebral ischemia-reperfusion injury, which may be related with the suppressed expressions of caspase-3 and bax. Twit Text FOAVip Effects of magnesium sulfate on neuron apoptosis and expression of caspase-3, bax and bcl-2 after cerebral ischemia-reperfusion injury ????Chin Med J (Engl) http://www.kidney.de/pget.php?&tw=1&pmid=14570617 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=14570617 #FOAvip English Wikipedia <ref>{{Cite pmid|14570617}}</ref> Effects of magnesium sulfate on neuron apoptosis and expression of caspase-3, bax and bcl-2 after cerebral ischemia-reperfusion injury #MMPMID14570617 Zhou H; Ma Y; Zhou Y; Liu Z; Wang K; Chen G Chin Med J (Engl) 2003[Oct]; 116 (10): 1532-4 PMID14570617show ga OBJECTIVE: To investigate the effects of magnesium sulfate on neuron apoptosis and the expressions of caspase-3, bax and bcl-2 after cerebral ischemia-reperfusion injury. METHODS: Thirty-six gerbils were randomly divided into three groups: Sham-operation group (So, n = 12), ischemia-reperfusion group (I-R, n = 12) and magnesium sulfate group (Ms, n = 12). The neuron apoptosis was detected by the terminal deoxynucleotidyl transferase (TdT)-mediated dUTP-fluorescence nick end labeling (TUNEL stain), and the protein expressions of caspase-3, bax and bcl-2 were detected by immunohistochemisty stain. RESULTS: Apoptotic neurons and the expressions of caspase-3 and bax were significantly increased in I-R and Ms groups, compared with those in So group. Apoptotic neurons and the expressions of bax and caspase-3 in Ms group were significantly less than those in I-R group. There was no significant difference in the expression of bcl-2 among three groups. CONCLUSIONS: Magnesium sulfate decreases neuron apoptosis after cerebral ischemia-reperfusion injury, which may be related with the suppressed expressions of caspase-3 and bax. |Animals[MESH] |Apoptosis/*drug effects[MESH] |Caspase 3[MESH] |Caspases/*analysis[MESH] |Cerebrovascular Disorders/*metabolism/*pathology[MESH] |Gerbillinae[MESH] |Magnesium Sulfate/*pharmacology[MESH] |Neurons/cytology/*drug effects[MESH] |Proto-Oncogene Proteins c-bcl-2/*analysis[MESH] |Proto-Oncogene Proteins/*analysis[MESH] |Random Allocation[MESH] |Reperfusion Injury/*metabolism/*pathology[MESH]Effects of magnesium sulfate on neuron apoptosis and expression of cas(epmc).pdf DeepDyve Pubget Overpricing