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10.4049/jimmunol.173.7.4675 http://scihub22266oqcxt.onion/10.4049/jimmunol.173.7.4675 15383603!ä!15383603 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\15383603.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Immunol 2004 ; 173 (7): 4675-83 Nephropedia Template TP {{tp|p=15383603|t=2004. Human parvovirus B19 transgenic mice become susceptible to polyarthritis |pdf=|usr=}}{{15383603}} gab.com Text Human parvovirus B19 transgenic mice become susceptible to polyarthritis JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=15383603 #FOAvip Human parvovirus B19 (B19) often causes acute polyarthritis in adults. In this paper, we analyzed nucleotide sequences of the B19 genome of patients with rheumatoid arthritis (RA), and then introduced the nonstructural protein 1 (NS1) gene of B19 into C57BL/6 mice that had a genetic origin not susceptible to arthritis. The transgenic mice developed no lesions spontaneously, but were susceptible to type II collagen (CII)-induced arthritis. B19 NS1 was expressed in synovial cells on the articular lesions that were histologically characteristic of granulomatous synovitis and pannus formation in cartilage and bone. Serum levels of anti-CII Abs and TNF-alpha increased in NS1 transgenic mice to the same levels as those of DBA/1 mice, which were susceptible to polyarthritis. Stimulation with CII increased secretion of Th1-type- and Th2-type cytokines in NS1 transgenic mice, indicating that a nonpermissive H-2(b) haplotype in the wild type of C57BL/6 mice can be made susceptible to polyarthritis through the expression of NS1. This study is the first to show that a viral agent from the joints in humans can cause CII-induced arthritis resembling RA. Twit Text FOAVip Human parvovirus B19 transgenic mice become susceptible to polyarthritis ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=15383603 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=15383603 #FOAvip English Wikipedia <ref>{{Cite pmid|15383603}}</ref> Human parvovirus B19 transgenic mice become susceptible to polyarthritis #MMPMID15383603 Takasawa N; Munakata Y; Ishii KK; Takahashi Y; Takahashi M; Fu Y; Ishii T; Fujii H; Saito T; Takano H; Noda T; Suzuki M; Nose M; Zolla-Patzner S; Sasaki T J Immunol 2004[Oct]; 173 (7): 4675-83 PMID15383603show ga Human parvovirus B19 (B19) often causes acute polyarthritis in adults. In this paper, we analyzed nucleotide sequences of the B19 genome of patients with rheumatoid arthritis (RA), and then introduced the nonstructural protein 1 (NS1) gene of B19 into C57BL/6 mice that had a genetic origin not susceptible to arthritis. The transgenic mice developed no lesions spontaneously, but were susceptible to type II collagen (CII)-induced arthritis. B19 NS1 was expressed in synovial cells on the articular lesions that were histologically characteristic of granulomatous synovitis and pannus formation in cartilage and bone. Serum levels of anti-CII Abs and TNF-alpha increased in NS1 transgenic mice to the same levels as those of DBA/1 mice, which were susceptible to polyarthritis. Stimulation with CII increased secretion of Th1-type- and Th2-type cytokines in NS1 transgenic mice, indicating that a nonpermissive H-2(b) haplotype in the wild type of C57BL/6 mice can be made susceptible to polyarthritis through the expression of NS1. This study is the first to show that a viral agent from the joints in humans can cause CII-induced arthritis resembling RA. |*Genetic Predisposition to Disease[MESH] |Animals[MESH] |Arthritis, Experimental/*genetics/immunology/pathology/*virology[MESH] |Arthritis, Rheumatoid/genetics/virology[MESH] |Autoantibodies/blood[MESH] |Base Sequence[MESH] |Collagen Type II/administration & dosage/immunology[MESH] |Crosses, Genetic[MESH] |Female[MESH] |Humans[MESH] |Lymph Nodes/immunology/pathology/virology[MESH] |Male[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH] |Mice, Inbred DBA[MESH] |Mice, Transgenic/*virology[MESH] |Molecular Sequence Data[MESH] |Parvovirus B19, Human/*genetics/immunology[MESH] |Synovial Membrane/pathology/virology[MESH] |Tumor Necrosis Factor-alpha/metabolism[MESH]Human parvovirus B19 transgenic mice become susceptible to polyarthrit(epmc).pdf DeepDyve Pubget Overpricing