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10.1161/01.CIR.0000146891.31481.CF http://scihub22266oqcxt.onion/10.1161/01.CIR.0000146891.31481.CF 15505098!ä!15505098 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=15505098&cmd=llinks): Failed to open stream: HTTP request failed! 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Endothelium-dependent flow-mediated vasodilation of systemic arteries is impaired in patients with myocardial virus persistence |pdf=|usr=}}{{15505098}} gab.com Text Endothelium-dependent flow-mediated vasodilation of systemic arteries is impaired in patients with myocardial virus persistence JO: Circulation http://www.kidney.de/pget.php?&tw=1&pmid=15505098 #FOAvip BACKGROUND: Myocardial virus persistence is frequently observed in patients with cardiomyopathy. Endothelial dysfunction in patients with cardiomyopathy is associated with inflammatory immunoresponses in myocardial biopsies. The aim of this study was to investigate the impact of myocardial virus persistence on endothelial function. METHODS AND RESULTS: In 124 patients with suspected cardiomyopathy, myocardial biopsies were examined for virus persistence (by polymerase chain reaction) and inflammation (by immunohistology). Endothelial function of the radial artery was examined by high-resolution ultrasound. Diameter changes in response to reactive hyperemia (flow-mediated dilation [FMD]) compared with glycerol trinitrate (GTN-MD) were measured. Mean age of the patients (55 men, 69 women) was 45+/-13 years; ejection fraction was 57+/-17%. In 73 patients, adenovirus, enterovirus, parvovirus, or HHV6 virus (V) was detected; in 51, no virus was detected. FMD was significantly impaired in patients with myocardial virus persistence compared with control subjects (Co): FMD-V, 3.38+/-2.67%; FMD-Co, 7.34+/-3.44 (P<0.001). In 86 patients, myocardial inflammation was confirmed (Inf). Of those, 57 had virus, and 29 did not. FMD was significantly impaired in patients with virus compared with controls: FMD-Inf-V, 3.24+/-2.66%; FMD-Inf-Co, 6.07+/-3.00 (P<0.001). In 38 patients, immunohistology of the myocardial biopsies was normal (Co); of those, 16 had virus, and 22 did not. FMD was impaired in patients with virus compared with control subjects: FMD-Co-V, 3.88+/-2.72%; FMD-Co-Co, 9.00+/-3.32% (P<0.001). Endothelium-independent vasodilation (GTN-MD) was not significantly affected. CONCLUSIONS: Myocardial virus persistence is associated with endothelial dysfunction. Endothelial dysfunction in patients with myocardial virus persistence can occur independently of endothelial activation or myocardial inflammation but is more pronounced in patients with concurrent inflammation. Twit Text FOAVip Endothelium-dependent flow-mediated vasodilation of systemic arteries is impaired in patients with myocardial virus persistence ????Circulation http://www.kidney.de/pget.php?&tw=1&pmid=15505098 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=15505098 #FOAvip English Wikipedia <ref>{{Cite pmid|15505098}}</ref> Endothelium-dependent flow-mediated vasodilation of systemic arteries is impaired in patients with myocardial virus persistence #MMPMID15505098 Vallbracht KB; Schwimmbeck PL; Kuhl U; Seeberg B; Schultheiss HP Circulation 2004[Nov]; 110 (18): 2938-45 PMID15505098show ga BACKGROUND: Myocardial virus persistence is frequently observed in patients with cardiomyopathy. Endothelial dysfunction in patients with cardiomyopathy is associated with inflammatory immunoresponses in myocardial biopsies. The aim of this study was to investigate the impact of myocardial virus persistence on endothelial function. METHODS AND RESULTS: In 124 patients with suspected cardiomyopathy, myocardial biopsies were examined for virus persistence (by polymerase chain reaction) and inflammation (by immunohistology). Endothelial function of the radial artery was examined by high-resolution ultrasound. Diameter changes in response to reactive hyperemia (flow-mediated dilation [FMD]) compared with glycerol trinitrate (GTN-MD) were measured. Mean age of the patients (55 men, 69 women) was 45+/-13 years; ejection fraction was 57+/-17%. In 73 patients, adenovirus, enterovirus, parvovirus, or HHV6 virus (V) was detected; in 51, no virus was detected. FMD was significantly impaired in patients with myocardial virus persistence compared with control subjects (Co): FMD-V, 3.38+/-2.67%; FMD-Co, 7.34+/-3.44 (P<0.001). In 86 patients, myocardial inflammation was confirmed (Inf). Of those, 57 had virus, and 29 did not. FMD was significantly impaired in patients with virus compared with controls: FMD-Inf-V, 3.24+/-2.66%; FMD-Inf-Co, 6.07+/-3.00 (P<0.001). In 38 patients, immunohistology of the myocardial biopsies was normal (Co); of those, 16 had virus, and 22 did not. FMD was impaired in patients with virus compared with control subjects: FMD-Co-V, 3.88+/-2.72%; FMD-Co-Co, 9.00+/-3.32% (P<0.001). Endothelium-independent vasodilation (GTN-MD) was not significantly affected. CONCLUSIONS: Myocardial virus persistence is associated with endothelial dysfunction. Endothelial dysfunction in patients with myocardial virus persistence can occur independently of endothelial activation or myocardial inflammation but is more pronounced in patients with concurrent inflammation. |Adenovirus Infections, Human/blood/*physiopathology/virology[MESH] |Adenoviruses, Human/isolation & purification[MESH] |Arteries/*physiopathology[MESH] |Biopsy[MESH] |C-Reactive Protein/analysis[MESH] |Cardiomyopathies/physiopathology[MESH] |Coxsackievirus Infections/blood/*physiopathology/virology[MESH] |DNA, Viral/isolation & purification[MESH] |Endothelium, Vascular/*physiopathology[MESH] |Enterovirus Infections/blood/*physiopathology/virology[MESH] |Enterovirus/isolation & purification[MESH] |Heart/*virology[MESH] |Hemodynamics[MESH] |Hemorheology[MESH] |Herpesvirus 4, Human/isolation & purification[MESH] |Herpesvirus 6, Human/isolation & purification[MESH] |Humans[MESH] |Myocarditis/blood/physiopathology/*virology[MESH] |Myocardium/pathology[MESH] |Parvoviridae Infections/blood/*physiopathology/virology[MESH] |Parvovirus B19, Human/isolation & purification[MESH] |Roseolovirus Infections/blood/*physiopathology/virology[MESH]Endothelium-dependent flow-mediated vasodilation of systemic arteries (epmc).pdf DeepDyve Pubget Overpricing