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10.1080/10245330400026154 http://scihub22266oqcxt.onion/10.1080/10245330400026154 16019474!ä!16019474 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\16019474.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Hematology 2005 ; 10 (3): 255-9 Nephropedia Template TP {{tp|p=16019474|t=2005. Acquired red cell aplasia in association with the use of recombinant erythropoietin in chronic renal failure |pdf=|usr=}}{{16019474}} gab.com Text Acquired red cell aplasia in association with the use of recombinant erythropoietin in chronic renal failure JO: Hematology http://www.kidney.de/pget.php?&tw=1&pmid=16019474 #FOAvip Acquired pure red cell aplasia (PRCA) is a rare condition. Traditionally it has been described in association with various etiologies such as parvovirus B19 infection, auto-immune disorders and drugs. Immunologically mediated PRCA is by far the commonest cause in adults, particularly since 1998, when a marked increased incidence of PRCA was noted in chronic renal failure patients receiving subcutaneous (SC) recombinant erythropoietin (rEpo). Typically these patients had been given erythropoietin for correction of anemia of renal failure and subsequently present with severe transfusion dependent anemia. Most cases were associated with SC administration of human serum albumin (HSA) free erythropoieitin alfa product (Eprex). Early recognition and withdrawal of erythropoietin therapy is essential. Treatment with immunosuppressive therapy, particularly in conjunction with renal transplant results in good response with resolution in the majority of cases. The pathogenesis is related to interaction of multiple factors such as formulation change and improper storage leading to increased immunogenicity of the recombinant product. The incidence peaked in 2001 and 2002, subsequently dropping considerably from 2003. This can be explained by the institution of measures such as more stringent handling and storage conditions, improvements in formulation of HSA free Eprex and switch to intravenous (IV) administration for Eprex in dialysis patients. The evidence to date on this condition is summarized in this review. Twit Text FOAVip Acquired red cell aplasia in association with the use of recombinant erythropoietin in chronic renal failure ????Hematology http://www.kidney.de/pget.php?&tw=1&pmid=16019474 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=16019474 #FOAvip English Wikipedia <ref>{{Cite pmid|16019474}}</ref> Acquired red cell aplasia in association with the use of recombinant erythropoietin in chronic renal failure #MMPMID16019474 Lim LC Hematology 2005[Jun]; 10 (3): 255-9 PMID16019474show ga Acquired pure red cell aplasia (PRCA) is a rare condition. Traditionally it has been described in association with various etiologies such as parvovirus B19 infection, auto-immune disorders and drugs. Immunologically mediated PRCA is by far the commonest cause in adults, particularly since 1998, when a marked increased incidence of PRCA was noted in chronic renal failure patients receiving subcutaneous (SC) recombinant erythropoietin (rEpo). Typically these patients had been given erythropoietin for correction of anemia of renal failure and subsequently present with severe transfusion dependent anemia. Most cases were associated with SC administration of human serum albumin (HSA) free erythropoieitin alfa product (Eprex). Early recognition and withdrawal of erythropoietin therapy is essential. Treatment with immunosuppressive therapy, particularly in conjunction with renal transplant results in good response with resolution in the majority of cases. The pathogenesis is related to interaction of multiple factors such as formulation change and improper storage leading to increased immunogenicity of the recombinant product. The incidence peaked in 2001 and 2002, subsequently dropping considerably from 2003. This can be explained by the institution of measures such as more stringent handling and storage conditions, improvements in formulation of HSA free Eprex and switch to intravenous (IV) administration for Eprex in dialysis patients. The evidence to date on this condition is summarized in this review. |Autoimmune Diseases/complications/*drug therapy/etiology[MESH] |Epoetin Alfa[MESH] |Erythropoietin/administration & dosage/*adverse effects[MESH] |Humans[MESH] |Incidence[MESH] |Kidney Failure, Chronic/complications/*therapy[MESH] |Parvoviridae Infections/complications[MESH] |Parvovirus[MESH] |Recombinant Proteins[MESH]Acquired red cell aplasia in association with the use of recombinant (epmc).pdf DeepDyve Pubget Overpricing