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10.1002/jmv.20514 http://scihub22266oqcxt.onion/10.1002/jmv.20514 16299714!ä!16299714 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\16299714.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Med+Virol 2006 ; 78 (1): 129-33 Nephropedia Template TP {{tp|p=16299714|t=2006. Aberrant cellular immune responses in humans infected persistently with parvovirus B19 |pdf=|usr=}}{{16299714}} gab.com Text Aberrant cellular immune responses in humans infected persistently with parvovirus B19 JO: J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=16299714 #FOAvip A subset of parvovirus B19 (B19) infected patients retains the infection for years, as defined by detection of B19 DNA in bone marrow. Thus far, analysis of B19-specific humoral immune responses and viral genome variations has not revealed a mechanism for the absent viral clearance. In this study, ex-vivo cellular immune responses were assessed by enzyme linked immunospot assay mounted against the majority of the translated viral genome. Compared to seropositive healthy individuals, individuals with B19 persistence (2-8 years) showed larger number of responses to the structural proteins (P = 0.0022), whereas responses to the non-structural protein were of lower magnitude (P = 0.012). These observations provide the first findings of immunological discrepancies between individuals with B19 persistence and healthy individuals, findings that may reflect both failed immunity and antigenic exhaustion. Twit Text FOAVip Aberrant cellular immune responses in humans infected persistently with parvovirus B19 ????J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=16299714 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=16299714 #FOAvip English Wikipedia <ref>{{Cite pmid|16299714}}</ref> Aberrant cellular immune responses in humans infected persistently with parvovirus B19 #MMPMID16299714 Isa A; Norbeck O; Hirbod T; Lundqvist A; Kasprowicz V; Bowness P; Klenerman P; Broliden K; Tolfvenstam T J Med Virol 2006[Jan]; 78 (1): 129-33 PMID16299714show ga A subset of parvovirus B19 (B19) infected patients retains the infection for years, as defined by detection of B19 DNA in bone marrow. Thus far, analysis of B19-specific humoral immune responses and viral genome variations has not revealed a mechanism for the absent viral clearance. In this study, ex-vivo cellular immune responses were assessed by enzyme linked immunospot assay mounted against the majority of the translated viral genome. Compared to seropositive healthy individuals, individuals with B19 persistence (2-8 years) showed larger number of responses to the structural proteins (P = 0.0022), whereas responses to the non-structural protein were of lower magnitude (P = 0.012). These observations provide the first findings of immunological discrepancies between individuals with B19 persistence and healthy individuals, findings that may reflect both failed immunity and antigenic exhaustion. |Adult[MESH] |Aged[MESH] |Antibodies, Viral/blood[MESH] |Enzyme-Linked Immunosorbent Assay[MESH] |Female[MESH] |Histocompatibility Testing[MESH] |Humans[MESH] |Immunoglobulin G/blood[MESH] |Immunoglobulin M/blood[MESH] |Interferon-gamma/*analysis[MESH] |Male[MESH] |Middle Aged[MESH] |Parvoviridae Infections/*immunology[MESH] |Parvovirus B19, Human/*immunology[MESH] |Viral Nonstructural Proteins/immunology[MESH]Aberrant cellular immune responses in humans infected persistently wit(epmc).pdf DeepDyve Pubget Overpricing