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10.1097/00000441-200608000-00004 http://scihub22266oqcxt.onion/10.1097/00000441-200608000-00004 16909053!ä!16909053 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\16909053.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Am+J+Med+Sci 2006 ; 332 (2): 73-78 Nephropedia Template TP {{tp|p=16909053|t=2006. Preventing oxidative stress in rats with aldosteronism by calcitriol and dietary calcium and magnesium supplements |pdf=|usr=}}{{16909053}} gab.com Text Preventing oxidative stress in rats with aldosteronism by calcitriol and dietary calcium and magnesium supplements JO: Am J Med Sci http://www.kidney.de/pget.php?&tw=1&pmid=16909053 #FOAvip BACKGROUND: Prominent features of the clinical syndrome of congestive heart failure (CHF) include aldosteronism and the presence of oxidative stress. Secondary hyperparathyroidism (SHPT) accompanies aldosteronism due to increased urinary and fecal excretion of Ca. SHPT accounts for intracellular Ca overloading of diverse cells, including peripheral blood mononuclear cells (PBMC), and the appearance of oxidative stress. Parathyroidectomy or a Ca channel blocker each prevent these responses. Herein, we hypothesized calcitriol, or 1,25(OH)2D3, plus a diet supplemented with Ca and Mg (CMD) would prevent SHPT and Ca overloading of PBMC and thereby oxidative stress in these cells in rats receiving aldosterone/salt treatment (ALDOST). METHODS AND RESULTS: In rats with ALDOST for 4 weeks, without or with CMD, we monitored plasma-ionized [Ca]o and parathyroid hormone (PTH), and PBMC cytosolic-free [Ca]i and H2O2 production. Untreated, age- and gender-matched rats served as controls. Compared to controls, ALDOST led to an expected fall in plasma [Ca]o level with accompanying rise in plasma PTH level and intracellular Ca overloading of PBMC and their increased production of H2O2. CMD prevented SHPT and abrogated intracellular Ca overloading of PBMC and their increased H2O2 production. CONCLUSIONS: The appearance of SHPT in aldosteronism, induced by fallen plasma [Ca]o, leads to PTH-mediated Ca overloading of PBMC and their increased production of H2O2. SHPT in rats with aldosteronism can be prevented by calcitriol and a diet supplemented with Ca and Mg. These findings raise the prospect that the SHPT found in CHF could be managed with macro- and micronutrients. Twit Text FOAVip Preventing oxidative stress in rats with aldosteronism by calcitriol and dietary calcium and magnesium supplements ????Am J Med Sci http://www.kidney.de/pget.php?&tw=1&pmid=16909053 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=16909053 #FOAvip English Wikipedia <ref>{{Cite pmid|16909053}}</ref> Preventing oxidative stress in rats with aldosteronism by calcitriol and dietary calcium and magnesium supplements #MMPMID16909053 Goodwin KD; Sun Y; Weber KT; Bhattacharya SK; Ahokas RA; Gerling IC Am J Med Sci 2006[Aug]; 332 (2): 73-78 PMID16909053show ga BACKGROUND: Prominent features of the clinical syndrome of congestive heart failure (CHF) include aldosteronism and the presence of oxidative stress. Secondary hyperparathyroidism (SHPT) accompanies aldosteronism due to increased urinary and fecal excretion of Ca. SHPT accounts for intracellular Ca overloading of diverse cells, including peripheral blood mononuclear cells (PBMC), and the appearance of oxidative stress. Parathyroidectomy or a Ca channel blocker each prevent these responses. Herein, we hypothesized calcitriol, or 1,25(OH)2D3, plus a diet supplemented with Ca and Mg (CMD) would prevent SHPT and Ca overloading of PBMC and thereby oxidative stress in these cells in rats receiving aldosterone/salt treatment (ALDOST). METHODS AND RESULTS: In rats with ALDOST for 4 weeks, without or with CMD, we monitored plasma-ionized [Ca]o and parathyroid hormone (PTH), and PBMC cytosolic-free [Ca]i and H2O2 production. Untreated, age- and gender-matched rats served as controls. Compared to controls, ALDOST led to an expected fall in plasma [Ca]o level with accompanying rise in plasma PTH level and intracellular Ca overloading of PBMC and their increased production of H2O2. CMD prevented SHPT and abrogated intracellular Ca overloading of PBMC and their increased H2O2 production. CONCLUSIONS: The appearance of SHPT in aldosteronism, induced by fallen plasma [Ca]o, leads to PTH-mediated Ca overloading of PBMC and their increased production of H2O2. SHPT in rats with aldosteronism can be prevented by calcitriol and a diet supplemented with Ca and Mg. These findings raise the prospect that the SHPT found in CHF could be managed with macro- and micronutrients. |*Dietary Supplements[MESH] |Aldosterone/pharmacology/toxicity[MESH] |Animals[MESH] |Calcitriol/*administration & dosage[MESH] |Calcium/*administration & dosage/blood/urine[MESH] |Cytoplasm/metabolism[MESH] |Heart Failure/blood/complications/diet therapy/urine[MESH] |Humans[MESH] |Hydrogen Peroxide/metabolism[MESH] |Hyperaldosteronism/blood/chemically induced/*diet therapy/urine[MESH] |Hyperparathyroidism, Secondary/blood/etiology/prevention & control/urine[MESH] |Leukocytes, Mononuclear/metabolism[MESH] |Magnesium/*administration & dosage/blood/urine[MESH] |Male[MESH] |Oxidative Stress/*drug effects[MESH] |Parathyroid Hormone/blood[MESH] |Rats[MESH]Preventing oxidative stress in rats with aldosteronism by calcitriol a(epmc).pdf DeepDyve Pubget Overpricing