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10.1016/j.trsl.2007.01.002 http://scihub22266oqcxt.onion/10.1016/j.trsl.2007.01.002 17466922!1974875!17466922     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\17466922.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Transl+Res 2007 ; 149 (5): 237-42 Nephropedia Template TP {{tp|p=17466922|t=2007. Transcriptional regulation of podocyte disease |pdf=|usr=}}{{17466922}} gab.com Text Transcriptional regulation of podocyte disease JO: Transl Res http://www.kidney.de/pget.php?&tw=1&pmid=17466922 #FOAvip The podocyte is a highly specialized visceral epithelial cell that forms the outermost layer of the glomerular capillary loop and plays a critical role in the maintenance of the glomerular filtration barrier. Several transcriptional factors regulate the podocyte function under normal and disease conditions. In this review, the role of Wilms tumor 1 (WT1), LIM homeobox transcription factor 1, beta (Lmx1b), pod1, pax-2, kreisler, nuclear factor-kappa B (NF-kappaB), smad7, and zinc fingers and homeoboxes (ZHX) proteins in the development of podocyte disease is outlined. The regulation of several important podocyte genes, including transcriptional factors, by ZHX proteins, their predominant non-nuclear localization in the normal in vivo podocyte, and changes in ZHX expression related to the development of minimal change disease and focal and segmental glomerulosclerosis are discussed. Finally, some future therapeutic strategies for glomerular disease are proposed. Twit Text FOAVip Transcriptional regulation of podocyte disease ????Transl Res http://www.kidney.de/pget.php?&tw=1&pmid=17466922 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=17466922 #FOAvip English Wikipedia <ref>{{Cite pmid|17466922}}</ref> Transcriptional regulation of podocyte disease #MMPMID17466922 Chugh SS Transl Res 2007[May]; 149 (5): 237-42 PMID17466922show ga The podocyte is a highly specialized visceral epithelial cell that forms the outermost layer of the glomerular capillary loop and plays a critical role in the maintenance of the glomerular filtration barrier. Several transcriptional factors regulate the podocyte function under normal and disease conditions. In this review, the role of Wilms tumor 1 (WT1), LIM homeobox transcription factor 1, beta (Lmx1b), pod1, pax-2, kreisler, nuclear factor-kappa B (NF-kappaB), smad7, and zinc fingers and homeoboxes (ZHX) proteins in the development of podocyte disease is outlined. The regulation of several important podocyte genes, including transcriptional factors, by ZHX proteins, their predominant non-nuclear localization in the normal in vivo podocyte, and changes in ZHX expression related to the development of minimal change disease and focal and segmental glomerulosclerosis are discussed. Finally, some future therapeutic strategies for glomerular disease are proposed. |*Gene Expression Regulation[MESH] |*Transcription, Genetic[MESH] |Animals[MESH] |Humans[MESH] |Kidney Diseases/*genetics/*metabolism[MESH] |Podocytes/*metabolism[MESH]Transcriptional regulation of podocyte disease (epmc).pdf DeepDyve Pubget Overpricing