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10.1136/ard.2007.071936 http://scihub22266oqcxt.onion/10.1136/ard.2007.071936 17911225!�!17911225 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=17911225&cmd=llinks): Failed to open stream: HTTP request failed! 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Outcomes from studies of antineutrophil cytoplasm antibody associated vasculitis: a systematic review by the European League Against Rheumatism systemic vasculitis task force |pdf=|usr=}}{{17911225}} gab.com Text Outcomes from studies of antineutrophil cytoplasm antibody associated vasculitis: a systematic review by the European League Against Rheumatism systemic vasculitis task force JO: Ann Rheum Dis http://www.kidney.de/pget.php?&tw=1&pmid=17911225 #FOAvip OBJECTIVES: We undertook a systematic literature review as a background to the European League Against Rheumatism (EULAR) recommendations for conducting clinical trials in anti-neutrophil cytoplasm antibody associated vasculitis (AAV), and to assess the quality of evidence for outcome measures in AAV. METHODS: Using a systematic Medline search, we categorised the identified studies according to diagnoses. Factors affecting remission, relapse, renal function and overall survival were identified. RESULTS: A total of 44 papers were reviewed from 502 identified by our search criteria. There was considerable inconsistency in definitions of end points. Remission rates varied from 30% to 93% in Wegener granulomatosis (WG), 75% to 89% in microscopic polyangiitis (MPA) and 81% to 91% in Churg-Strauss syndrome (CSS). The 5-year survival for WG, MPA and CSS was 74-91%, 45-76% and 60-97%. Relapse (variably defined) was common in the first 2 years but the frequency varied: 18% to 60% in WG, 8% in MPA, and 35% in CSS. The rate of renal survival in WG varied from 23% at 15 months to 23% at 120 months. METHOD: used to assess morbidity varied between studies. Ignoring the variations in definitions of the stage of disease, factors influencing remission, relapse, renal and overall survival included immunosuppressive therapy used, type of organ involvement, presence of ANCA, older age and male gender. CONCLUSIONS: Factors influencing remission, relapse, renal and overall survival include the type of immunosuppressive therapy used, pattern of organ involvement, presence of ANCA, older age and male gender. Methodological variations between studies highlight the need for a consensus on terminology and definitions for future conduct of clinical studies in AAV. Twit Text FOAVip Outcomes from studies of antineutrophil cytoplasm antibody associated vasculitis: a systematic review by the European League Against Rheumatism systemic vasculitis task force ????Ann Rheum Dis http://www.kidney.de/pget.php?&tw=1&pmid=17911225 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=17911225 #FOAvip English Wikipedia <ref>{{Cite pmid|17911225}}</ref> Outcomes from studies of antineutrophil cytoplasm antibody associated vasculitis: a systematic review by the European League Against Rheumatism systemic vasculitis task force #MMPMID17911225 Mukhtyar C; Flossmann O; Hellmich B; Bacon P; Cid M; Cohen-Tervaert JW; Gross WL; Guillevin L; Jayne D; Mahr A; Merkel PA; Raspe H; Scott D; Witter J; Yazici H; Luqmani RA Ann Rheum Dis 2008[Jul]; 67 (7): 1004-10 PMID17911225show ga OBJECTIVES: We undertook a systematic literature review as a background to the European League Against Rheumatism (EULAR) recommendations for conducting clinical trials in anti-neutrophil cytoplasm antibody associated vasculitis (AAV), and to assess the quality of evidence for outcome measures in AAV. METHODS: Using a systematic Medline search, we categorised the identified studies according to diagnoses. Factors affecting remission, relapse, renal function and overall survival were identified. RESULTS: A total of 44 papers were reviewed from 502 identified by our search criteria. There was considerable inconsistency in definitions of end points. Remission rates varied from 30% to 93% in Wegener granulomatosis (WG), 75% to 89% in microscopic polyangiitis (MPA) and 81% to 91% in Churg-Strauss syndrome (CSS). The 5-year survival for WG, MPA and CSS was 74-91%, 45-76% and 60-97%. Relapse (variably defined) was common in the first 2 years but the frequency varied: 18% to 60% in WG, 8% in MPA, and 35% in CSS. The rate of renal survival in WG varied from 23% at 15 months to 23% at 120 months. METHOD: used to assess morbidity varied between studies. Ignoring the variations in definitions of the stage of disease, factors influencing remission, relapse, renal and overall survival included immunosuppressive therapy used, type of organ involvement, presence of ANCA, older age and male gender. CONCLUSIONS: Factors influencing remission, relapse, renal and overall survival include the type of immunosuppressive therapy used, pattern of organ involvement, presence of ANCA, older age and male gender. Methodological variations between studies highlight the need for a consensus on terminology and definitions for future conduct of clinical studies in AAV. |Antibodies, Antineutrophil Cytoplasmic/*blood[MESH] |Churg-Strauss Syndrome/drug therapy/immunology[MESH] |Cyclophosphamide/therapeutic use[MESH] |Evidence-Based Medicine[MESH] |Glucocorticoids/therapeutic use[MESH] |Granulomatosis with Polyangiitis/drug therapy[MESH] |Humans[MESH] |Immunosuppressive Agents/therapeutic use[MESH] |Recurrence[MESH] |Remission Induction[MESH] |Risk Factors[MESH] |Survival Analysis[MESH] |Treatment Outcome[MESH]Outcomes from studies of antineutrophil cytoplasm antibody associated (epmc).pdf DeepDyve Pubget Overpricing