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10.1159/000209207 http://scihub22266oqcxt.onion/10.1159/000209207 19293596!2851161!19293596     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\19293596.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nephron+Exp+Nephrol 2009 ; 111 (4): e73-9 Nephropedia Template TP {{tp|p=19293596|t=2009. The pathogenic role of Notch activation in podocytes |pdf=|usr=}}{{19293596}} gab.com Text The pathogenic role of Notch activation in podocytes JO: Nephron Exp Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=19293596 #FOAvip Podocytes play a key role in the maintenance of the glomerular filtration barrier. Depletion or dysregulative mechanisms of podocytes can lead to the development of glomerulosclerosis. Signaling pathways that control these processes in podocytes are not fully understood. Recent studies from our and other laboratories found that genes that belong to the Notch pathway are regulated in patients and in animal models of renal disease. Genetic studies performed on mice with conditional expression of active Notch1 protein showed massive albuminuria, glomerulosclerosis, and ultimately renal failure and death of the animals. gamma-Secretase inhibitors and genetic deletion of Notch transcriptional binding partner (Rbpj) protected animals from nephrotic syndrome. Further studies are needed to define whether the activation of Notch pathway in podocytes represents a common pathomechanism in glomerular injury, and its potential to be a therapeutic target for the treatment of chronic kidney disease. Twit Text FOAVip The pathogenic role of Notch activation in podocytes ????Nephron Exp Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=19293596 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=19293596 #FOAvip English Wikipedia <ref>{{Cite pmid|19293596}}</ref> The pathogenic role of Notch activation in podocytes #MMPMID19293596 Niranjan T; Murea M; Susztak K Nephron Exp Nephrol 2009[]; 111 (4): e73-9 PMID19293596show ga Podocytes play a key role in the maintenance of the glomerular filtration barrier. Depletion or dysregulative mechanisms of podocytes can lead to the development of glomerulosclerosis. Signaling pathways that control these processes in podocytes are not fully understood. Recent studies from our and other laboratories found that genes that belong to the Notch pathway are regulated in patients and in animal models of renal disease. Genetic studies performed on mice with conditional expression of active Notch1 protein showed massive albuminuria, glomerulosclerosis, and ultimately renal failure and death of the animals. gamma-Secretase inhibitors and genetic deletion of Notch transcriptional binding partner (Rbpj) protected animals from nephrotic syndrome. Further studies are needed to define whether the activation of Notch pathway in podocytes represents a common pathomechanism in glomerular injury, and its potential to be a therapeutic target for the treatment of chronic kidney disease. |Animals[MESH] |Humans[MESH] |Kidney Diseases/etiology/metabolism/pathology[MESH] |Podocytes/cytology/*metabolism/*pathology/physiology[MESH]The pathogenic role of Notch activation in podocytes (epmc).pdf DeepDyve Pubget Overpricing