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10.2337/db09-0014 http://scihub22266oqcxt.onion/10.2337/db09-0014 19411615!2699868!19411615     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\19411615.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Diabetes 2009 ; 58 (7): 1668-71 Nephropedia Template TP {{tp|p=19411615|t=2009. Serum uric acid as a predictor for development of diabetic nephropathy in type 1 diabetes: an inception cohort study |pdf=|usr=}}{{19411615}} gab.com Text Serum uric acid as a predictor for development of diabetic nephropathy in type 1 diabetes: an inception cohort study JO: Diabetes http://www.kidney.de/pget.php?&tw=1&pmid=19411615 #FOAvip OBJECTIVE: Experimental and clinical studies have suggested that uric acid may contribute to the development of hypertension and kidney disease. Whether uric acid has a causal role in the development of diabetic nephropathy is not known. The objective of the present study is to evaluate uric acid as a predictor of persistent micro- and macroalbuminuria. RESEARCH DESIGN AND METHODS: This prospective observational follow-up study consisted of an inception cohort of 277 patients followed from onset of type 1 diabetes. Of these, 270 patients had blood samples taken at baseline. In seven cases, uric acid could not be determined; therefore, 263 patients (156 men) were available for analysis. Uric acid was measured 3 years after onset of diabetes and before any patient developed microalbuminuria. RESULTS: During a median follow-up of 18.1 years (range 1.0-21.8), 23 of 263 patients developed persistent macroalbuminuria (urinary albumin excretion rate >300 mg/24 h in at least two of three consecutive samples). In patients with uric acid levels in the highest quartile (>249 micromol/l), the cumulative incidence of persistent macroalbumnuria was 22.3% (95% CI 10.3-34.3) compared with 9.5% (3.8-15.2) in patients with uric acid in the three lower quartiles (log-rank test, P = 0.006). In a Cox proportional hazards model with sex and age as fixed covariates, uric acid was associated with subsequent development of persistent macroalbuminuria (hazard ratio 2.37 [95% CI 1.04-5.37] per 100 micromol/l increase in uric acid level; P = 0.04). Adjustment for confounders did not change the estimate significantly. CONCLUSIONS: Uric acid level soon after onset of type 1 diabetes is independently associated with risk for later development of diabetic nephropathy. Twit Text FOAVip Serum uric acid as a predictor for development of diabetic nephropathy in type 1 diabetes: an inception cohort study ????Diabetes http://www.kidney.de/pget.php?&tw=1&pmid=19411615 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=19411615 #FOAvip English Wikipedia <ref>{{Cite pmid|19411615}}</ref> Serum uric acid as a predictor for development of diabetic nephropathy in type 1 diabetes: an inception cohort study #MMPMID19411615 Hovind P; Rossing P; Tarnow L; Johnson RJ; Parving HH Diabetes 2009[Jul]; 58 (7): 1668-71 PMID19411615show ga OBJECTIVE: Experimental and clinical studies have suggested that uric acid may contribute to the development of hypertension and kidney disease. Whether uric acid has a causal role in the development of diabetic nephropathy is not known. The objective of the present study is to evaluate uric acid as a predictor of persistent micro- and macroalbuminuria. RESEARCH DESIGN AND METHODS: This prospective observational follow-up study consisted of an inception cohort of 277 patients followed from onset of type 1 diabetes. Of these, 270 patients had blood samples taken at baseline. In seven cases, uric acid could not be determined; therefore, 263 patients (156 men) were available for analysis. Uric acid was measured 3 years after onset of diabetes and before any patient developed microalbuminuria. RESULTS: During a median follow-up of 18.1 years (range 1.0-21.8), 23 of 263 patients developed persistent macroalbuminuria (urinary albumin excretion rate >300 mg/24 h in at least two of three consecutive samples). In patients with uric acid levels in the highest quartile (>249 micromol/l), the cumulative incidence of persistent macroalbumnuria was 22.3% (95% CI 10.3-34.3) compared with 9.5% (3.8-15.2) in patients with uric acid in the three lower quartiles (log-rank test, P = 0.006). In a Cox proportional hazards model with sex and age as fixed covariates, uric acid was associated with subsequent development of persistent macroalbuminuria (hazard ratio 2.37 [95% CI 1.04-5.37] per 100 micromol/l increase in uric acid level; P = 0.04). Adjustment for confounders did not change the estimate significantly. CONCLUSIONS: Uric acid level soon after onset of type 1 diabetes is independently associated with risk for later development of diabetic nephropathy. |Adolescent[MESH] |Adult[MESH] |Albuminuria/epidemiology[MESH] |Blood Pressure[MESH] |Cohort Studies[MESH] |Diabetes Mellitus, Type 1/*complications[MESH] |Diabetic Nephropathies/blood/*epidemiology[MESH] |Female[MESH] |Follow-Up Studies[MESH] |Humans[MESH] |Incidence[MESH] |Male[MESH] |Predictive Value of Tests[MESH] |Prospective Studies[MESH] |Risk Factors[MESH] |Time Factors[MESH] |Uric Acid/*blood[MESH]Serum uric acid as a predictor for development of diabetic nephropathy(epmc).pdf DeepDyve Pubget Overpricing