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10.1086/605413 http://scihub22266oqcxt.onion/10.1086/605413 19656068!7110194!19656068     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=19656068&cmd=llinks): Failed to open stream: HTTP request failed! 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Phosphoantigen-expanded human gammadelta T cells display potent cytotoxicity against monocyte-derived macrophages infected with human and avian influenza viruses |pdf=|usr=}}{{19656068}} gab.com Text Phosphoantigen-expanded human gammadelta T cells display potent cytotoxicity against monocyte-derived macrophages infected with human and avian influenza viruses JO: J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=19656068 #FOAvip BACKGROUND: Influenza virus is a cause of substantial annual morbidity and mortality worldwide. The potential emergence of a new pandemic strain (eg, avian influenza virus) is a major concern. Currently available vaccines and anti-influenza drugs have limited effectiveness for influenza virus infections, especially for new pandemic strains. Therefore, there is an acute need to develop alternative strategies for influenza therapy. gammadelta T cells have potent antiviral activities against different viruses, but no data are available concerning their antiviral activity against influenza viruses. METHODS: In this study, we used virus-infected primary human monocyte-derived macrophages (MDMs) to examine the antiviral activity of phosphoantigen isopentenyl pyrophosphate (IPP)-expanded human Vgamma9Vdelta2 T cells against influenza viruses. RESULTS: Vgamma9Vdelta2 T cells were selectively activated and expanded by IPP from peripheral blood mononuclear cells. IPP-expanded Vgamma9Vdelta2 T cells efficiently killed MDMs infected with human (H1N1) or avian (H9N2 or H5N1) influenza virus and significantly inhibited viral replication. The cytotoxicity of Vgamma9Vdelta2 T cells against influenza virus-infected MDMs was dependent on NKG2D activation and was mediated by Fas-Fas ligand and perforin-granzyme B pathways. CONCLUSION: Our findings suggest a potentially novel therapeutic approach to seasonal, zoonotic avian, and pandemic influenza-the use of phosphoantigens to activate gammadelta T cells against influenza virus infections. Twit Text FOAVip Phosphoantigen-expanded human gammadelta T cells display potent cytotoxicity against monocyte-derived macrophages infected with human and avian influenza viruses ????J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=19656068 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=19656068 #FOAvip English Wikipedia <ref>{{Cite pmid|19656068}}</ref> Phosphoantigen-expanded human gammadelta T cells display potent cytotoxicity against monocyte-derived macrophages infected with human and avian influenza viruses #MMPMID19656068 Qin G; Mao H; Zheng J; Sia SF; Liu Y; Chan PL; Lam KT; Peiris JS; Lau YL; Tu W J Infect Dis 2009[Sep]; 200 (6): 858-65 PMID19656068show ga BACKGROUND: Influenza virus is a cause of substantial annual morbidity and mortality worldwide. The potential emergence of a new pandemic strain (eg, avian influenza virus) is a major concern. Currently available vaccines and anti-influenza drugs have limited effectiveness for influenza virus infections, especially for new pandemic strains. Therefore, there is an acute need to develop alternative strategies for influenza therapy. gammadelta T cells have potent antiviral activities against different viruses, but no data are available concerning their antiviral activity against influenza viruses. METHODS: In this study, we used virus-infected primary human monocyte-derived macrophages (MDMs) to examine the antiviral activity of phosphoantigen isopentenyl pyrophosphate (IPP)-expanded human Vgamma9Vdelta2 T cells against influenza viruses. RESULTS: Vgamma9Vdelta2 T cells were selectively activated and expanded by IPP from peripheral blood mononuclear cells. IPP-expanded Vgamma9Vdelta2 T cells efficiently killed MDMs infected with human (H1N1) or avian (H9N2 or H5N1) influenza virus and significantly inhibited viral replication. The cytotoxicity of Vgamma9Vdelta2 T cells against influenza virus-infected MDMs was dependent on NKG2D activation and was mediated by Fas-Fas ligand and perforin-granzyme B pathways. CONCLUSION: Our findings suggest a potentially novel therapeutic approach to seasonal, zoonotic avian, and pandemic influenza-the use of phosphoantigens to activate gammadelta T cells against influenza virus infections. |*Hemiterpenes[MESH] |*Organophosphorus Compounds[MESH] |Animals[MESH] |Cytotoxicity, Immunologic[MESH] |Gene Expression Regulation/physiology[MESH] |Granzymes/metabolism[MESH] |Humans[MESH] |Influenza A Virus, H1N1 Subtype/*physiology[MESH] |Influenza A Virus, H5N1 Subtype/*physiology[MESH] |Influenza A Virus, H9N2 Subtype/*physiology[MESH] |Macrophages/virology[MESH] |NK Cell Lectin-Like Receptor Subfamily K/genetics/metabolism[MESH] |Perforin/metabolism[MESH] |Receptors, Antigen, T-Cell, gamma-delta/*immunology[MESH] |T-Lymphocytes/*immunology/metabolism[MESH]Phosphoantigen-expanded human gammadelta T cells display potent cytoto(epmc).pdf DeepDyve Pubget Overpricing