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10.1172/JCI39421 http://scihub22266oqcxt.onion/10.1172/JCI39421 19805915!2752080!19805915     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=19805915&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\19805915.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Clin+Invest 2009 ; 119 (10): 2868-78 Nephropedia Template TP {{tp|p=19805915|t=2009. Animal models of sepsis and sepsis-induced kidney injury |pdf=|usr=}}{{19805915}} gab.com Text Animal models of sepsis and sepsis-induced kidney injury JO: J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=19805915 #FOAvip Sepsis is characterized by a severe inflammatory response to infection, and its complications, including acute kidney injury, can be fatal. Animal models that correctly mimic human disease are extremely valuable because they hasten the development of clinically useful therapeutics. Too often, however, animal models do not properly mimic human disease. In this Review, we outline a bedside-to-bench-to-bedside approach that has resulted in improved animal models for the study of sepsis - a complex disease for which preventive and therapeutic strategies are unfortunately lacking. We also highlight a few of the promising avenues for therapeutic advances and biomarkers for sepsis and sepsis-induced acute kidney injury. Finally, we review how the study of drug targets and biomarkers are affected by and in turn have influenced these evolving animal models. Twit Text FOAVip Animal models of sepsis and sepsis-induced kidney injury ????J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=19805915 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=19805915 #FOAvip English Wikipedia <ref>{{Cite pmid|19805915}}</ref> Animal models of sepsis and sepsis-induced kidney injury #MMPMID19805915 Doi K; Leelahavanichkul A; Yuen PS; Star RA J Clin Invest 2009[Oct]; 119 (10): 2868-78 PMID19805915show ga Sepsis is characterized by a severe inflammatory response to infection, and its complications, including acute kidney injury, can be fatal. Animal models that correctly mimic human disease are extremely valuable because they hasten the development of clinically useful therapeutics. Too often, however, animal models do not properly mimic human disease. In this Review, we outline a bedside-to-bench-to-bedside approach that has resulted in improved animal models for the study of sepsis - a complex disease for which preventive and therapeutic strategies are unfortunately lacking. We also highlight a few of the promising avenues for therapeutic advances and biomarkers for sepsis and sepsis-induced acute kidney injury. Finally, we review how the study of drug targets and biomarkers are affected by and in turn have influenced these evolving animal models. |*Disease Models, Animal[MESH] |Acute Kidney Injury/*pathology/*physiopathology/therapy[MESH] |Animals[MESH] |Biomarkers/metabolism[MESH] |Hemodynamics[MESH] |Humans[MESH] |Inflammation Mediators/therapeutic use[MESH] |Inflammation/metabolism/pathology[MESH] |Kidney/*pathology[MESH] |Lipopolysaccharides/immunology[MESH] |Neuroimmunomodulation/physiology[MESH] |Sepsis/*pathology/*physiopathology/therapy[MESH]Animal models of sepsis and sepsis-induced kidney injury (epmc).pdf DeepDyve Pubget Overpricing