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10.1242/jcs.051326 http://scihub22266oqcxt.onion/10.1242/jcs.051326 20145000!ä!20145000 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\20145000.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Cell+Sci 2010 ; 123 (Pt 4): 519-28 Nephropedia Template TP {{tp|p=20145000|t=2010. Flagellar and ciliary beating: the proven and the possible |pdf=|usr=}}{{20145000}} gab.com Text Flagellar and ciliary beating: the proven and the possible JO: J Cell Sci http://www.kidney.de/pget.php?&tw=1&pmid=20145000 #FOAvip The working mechanism of the eukaryotic flagellar axoneme remains one of nature's most enduring puzzles. The basic mechanical operation of the axoneme is now a story that is fairly complete; however, the mechanism for coordinating the action of the dynein motor proteins to produce beating is still controversial. Although a full grasp of the dynein switching mechanism remains elusive, recent experimental reports provide new insights that might finally disclose the secrets of the beating mechanism: the special role of the inner dynein arms, especially dynein I1 and the dynein regulatory complex, the importance of the dynein microtubule-binding affinity at the stalk, and the role of bending in the selection of the active dynein group have all been implicated by major new evidence. This Commentary considers this new evidence in the context of various hypotheses of how axonemal dynein coordination might work. Twit Text FOAVip Flagellar and ciliary beating: the proven and the possible ????J Cell Sci http://www.kidney.de/pget.php?&tw=1&pmid=20145000 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=20145000 #FOAvip English Wikipedia <ref>{{Cite pmid|20145000}}</ref> Flagellar and ciliary beating: the proven and the possible #MMPMID20145000 Lindemann CB; Lesich KA J Cell Sci 2010[Feb]; 123 (Pt 4): 519-28 PMID20145000show ga The working mechanism of the eukaryotic flagellar axoneme remains one of nature's most enduring puzzles. The basic mechanical operation of the axoneme is now a story that is fairly complete; however, the mechanism for coordinating the action of the dynein motor proteins to produce beating is still controversial. Although a full grasp of the dynein switching mechanism remains elusive, recent experimental reports provide new insights that might finally disclose the secrets of the beating mechanism: the special role of the inner dynein arms, especially dynein I1 and the dynein regulatory complex, the importance of the dynein microtubule-binding affinity at the stalk, and the role of bending in the selection of the active dynein group have all been implicated by major new evidence. This Commentary considers this new evidence in the context of various hypotheses of how axonemal dynein coordination might work. |Animals[MESH] |Axoneme/physiology/ultrastructure[MESH] |Cilia/*physiology/ultrastructure[MESH] |Dyneins/physiology[MESH] |Flagella/*physiology/ultrastructure[MESH] |Humans[MESH] |Models, Biological[MESH] |Molecular Motor Proteins/physiology[MESH]Flagellar and ciliary beating: the proven and the possible (epmc).pdf DeepDyve Pubget Overpricing