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10.1242/jcs.062968 http://scihub22266oqcxt.onion/10.1242/jcs.062968 20145001!2818192!20145001     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\20145001.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Cell+Sci 2010 ; 123 (Pt 4): 529-36 Nephropedia Template TP {{tp|p=20145001|t=2010. Molecular mechanisms of protein and lipid targeting to ciliary membranes |pdf=|usr=}}{{20145001}} gab.com Text Molecular mechanisms of protein and lipid targeting to ciliary membranes JO: J Cell Sci http://www.kidney.de/pget.php?&tw=1&pmid=20145001 #FOAvip Cilia are specialized surface regions of eukaryotic cells that serve a variety of functions, ranging from motility to sensation and to regulation of cell growth and differentiation. The discovery that a number of human diseases, collectively known as ciliopathies, result from defective cilium function has expanded interest in these structures. Among the many properties of cilia, motility and intraflagellar transport have been most extensively studied. The latter is the process by which multiprotein complexes associate with microtubule motors to transport structural subunits along the axoneme to and from the ciliary tip. By contrast, the mechanisms by which membrane proteins and lipids are specifically targeted to the cilium are still largely unknown. In this Commentary, we review the current knowledge of protein and lipid targeting to ciliary membranes and outline important issues for future study. We also integrate this information into a proposed model of how the cell specifically targets proteins and lipids to the specialized membrane of this unique organelle. Twit Text FOAVip Molecular mechanisms of protein and lipid targeting to ciliary membranes ????J Cell Sci http://www.kidney.de/pget.php?&tw=1&pmid=20145001 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=20145001 #FOAvip English Wikipedia <ref>{{Cite pmid|20145001}}</ref> Molecular mechanisms of protein and lipid targeting to ciliary membranes #MMPMID20145001 Emmer BT; Maric D; Engman DM J Cell Sci 2010[Feb]; 123 (Pt 4): 529-36 PMID20145001show ga Cilia are specialized surface regions of eukaryotic cells that serve a variety of functions, ranging from motility to sensation and to regulation of cell growth and differentiation. The discovery that a number of human diseases, collectively known as ciliopathies, result from defective cilium function has expanded interest in these structures. Among the many properties of cilia, motility and intraflagellar transport have been most extensively studied. The latter is the process by which multiprotein complexes associate with microtubule motors to transport structural subunits along the axoneme to and from the ciliary tip. By contrast, the mechanisms by which membrane proteins and lipids are specifically targeted to the cilium are still largely unknown. In this Commentary, we review the current knowledge of protein and lipid targeting to ciliary membranes and outline important issues for future study. We also integrate this information into a proposed model of how the cell specifically targets proteins and lipids to the specialized membrane of this unique organelle. |Animals[MESH] |Axoneme/metabolism/ultrastructure[MESH] |Cilia/*metabolism/ultrastructure[MESH] |Golgi Apparatus/metabolism[MESH] |Humans[MESH] |Membrane Fusion[MESH] |Membrane Lipids/*metabolism[MESH] |Membrane Proteins/*metabolism[MESH] |Models, Biological[MESH] |Movement[MESH]Molecular mechanisms of protein and lipid targeting to ciliary membran(epmc).pdf DeepDyve Pubget Overpricing