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10.1093/ajh/4.2.169

http://scihub22266oqcxt.onion/10.1093/ajh/4.2.169
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2021448!ä!2021448

suck abstract from ncbi


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pmid2021448      Am+J+Hypertens 1991 ; 4 (2 Pt 1): 169-72
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  • Suppressive effect of sulfate on the development of hypertension in DOCA-salt hypertensive rats #MMPMID2021448
  • Kubota Y; Sano H; Kawahara J; Hattori K; Miki T; Suzuki H; Fukuzaki H
  • Am J Hypertens 1991[Feb]; 4 (2 Pt 1): 169-72 PMID2021448show ga
  • The purpose of this study was to examine the effect of the sulfate ion on blood pressure in DOCA-salt hypertension, which involves increased sympathetic nervous activity. Male Wistar rats were divided into four groups, and received one of the following drinking solutions: distilled water [control], 171 mmol/L sodium chloride [NaCl group], 171 mmol/L sodium chloride plus 12 mmol/L magnesium sulfate [S(+) group], or 171 mmol/L sodium chloride plus 12 mmol/L magnesium chloride [S(-) group]. In the S(+) group, the elevation of systolic blood pressure (SBP; mm Hg) was significantly attenuated (168 +/- 17 v 213 +/- 26, P less than .005) and intraerythrocyte calcium concentration (R-Ca; mumol/L cells) was significantly lower (11.5 +/- 3.0 v 17.4 +/- 6.5, P less than .05) than in the S(-) group. The cardiac norepinephrine content (H-NE; ng/100 g tissue) of the S(+) group was significantly lower than that of the S(-) group. SBP was correlated negatively with H-NE (r = -0.70, P less than .001) and positively with R-Ca (r = 0.45, P less than .005). R-Ca was negatively correlated with H-NE (r = -0.36, P less than .05). These results suggest that the replacement of chloride with sulfate ion suppresses the development of hypertension in DOCA-salt rats at least in part by its inhibitory effect on sympathetic nervous activity through the decreased intracellular calcium concentration.
  • |Administration, Oral[MESH]
  • |Animals[MESH]
  • |Blood Pressure/*drug effects[MESH]
  • |Calcium/metabolism[MESH]
  • |Desoxycorticosterone[MESH]
  • |Erythrocytes/metabolism[MESH]
  • |Hypertension/chemically induced/*etiology/physiopathology[MESH]
  • |Magnesium Chloride/administration & dosage/pharmacology[MESH]
  • |Magnesium Sulfate/administration & dosage/pharmacology[MESH]
  • |Male[MESH]
  • |Myocardium/metabolism[MESH]
  • |Norepinephrine/metabolism[MESH]
  • |Rats[MESH]
  • |Rats, Inbred Strains[MESH]
  • |Sodium Chloride/administration & dosage/pharmacology[MESH]
  • |Sulfates/*pharmacology[MESH]


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