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10.1684/mrh.2009.0195 http://scihub22266oqcxt.onion/10.1684/mrh.2009.0195 20228013!ä!20228013 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\20228013.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Magnes+Res 2010 ; 23 (1): 5-18 Nephropedia Template TP {{tp|p=20228013|t=2010. The biochemical function of Mg(2)+ in insulin secretion, insulin signal transduction and insulin resistance |pdf=|usr=}}{{20228013}} gab.com Text The biochemical function of Mg(2)+ in insulin secretion, insulin signal transduction and insulin resistance JO: Magnes Res http://www.kidney.de/pget.php?&tw=1&pmid=20228013 #FOAvip Insulin secretion is started by a Ca2+ influx that is competitively inhibited by extracellular Mg2+. This can explain the inverse correlation between serum Mg2+ and serum insulin concentration. After binding of insulin to its receptor, receptor tyrosine kinase is activated. The autophosphorylation of the receptor kinase and all protein kinases in the insulin signal transduction cascade are dependent on Mg2+. Besides MgATP as substrate, protein tyrosine kinases are activated by a second Mg2+. Other protein kinases and some protein phosphatases involved in insulin resistance are dependent on Mg2+ as well. In the complex action of Mg2+ on tyrosine protein kinases and serine/threonine kinases, which mediate or inhibit insulin signaling, the concentration of intracellular free Mg2+ ([Mg2+](i)) may have a permissive function. The secretion of various effectors such as adipokines, interleukin (IL)-1, IL-6, IL-8, IL-18, tumor necrosis factor-alpha (TNF-alpha), beta-adrenergics and reactive oxygen species (ROS) involved in insulin resistance is enhanced in Mg deficiency and obesity. Adipocytes produce chemotactic signals, leading to macrophage recruitment and in addition to adipocytes, to the production of proinflammatory cytokines. The concentration of free fatty acids (FFA), particularly palmitate, is increased in obesity and by the action of beta-adrenergics. The complex actions of adipokines, cytokines and palmitate in the induction of insulin resistance are reviewed. The concentration of extracellular and intracellular Mg2+ in patients and the experimental effects of insulin and catecholamines on [Mg2+](i) in various tissues are described. The controversial effects of different serum Mg2+ concentrations and Mg2+ supplementation on plasma glucose and insulin concentration in studies with human subjects and the controversial results of epidemiological studies are reported. Twit Text FOAVip The biochemical function of Mg(2)+ in insulin secretion, insulin signal transduction and insulin resistance ????Magnes Res http://www.kidney.de/pget.php?&tw=1&pmid=20228013 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=20228013 #FOAvip English Wikipedia <ref>{{Cite pmid|20228013}}</ref> The biochemical function of Mg(2)+ in insulin secretion, insulin signal transduction and insulin resistance #MMPMID20228013 Gunther T Magnes Res 2010[Mar]; 23 (1): 5-18 PMID20228013show ga Insulin secretion is started by a Ca2+ influx that is competitively inhibited by extracellular Mg2+. This can explain the inverse correlation between serum Mg2+ and serum insulin concentration. After binding of insulin to its receptor, receptor tyrosine kinase is activated. The autophosphorylation of the receptor kinase and all protein kinases in the insulin signal transduction cascade are dependent on Mg2+. Besides MgATP as substrate, protein tyrosine kinases are activated by a second Mg2+. Other protein kinases and some protein phosphatases involved in insulin resistance are dependent on Mg2+ as well. In the complex action of Mg2+ on tyrosine protein kinases and serine/threonine kinases, which mediate or inhibit insulin signaling, the concentration of intracellular free Mg2+ ([Mg2+](i)) may have a permissive function. The secretion of various effectors such as adipokines, interleukin (IL)-1, IL-6, IL-8, IL-18, tumor necrosis factor-alpha (TNF-alpha), beta-adrenergics and reactive oxygen species (ROS) involved in insulin resistance is enhanced in Mg deficiency and obesity. Adipocytes produce chemotactic signals, leading to macrophage recruitment and in addition to adipocytes, to the production of proinflammatory cytokines. The concentration of free fatty acids (FFA), particularly palmitate, is increased in obesity and by the action of beta-adrenergics. The complex actions of adipokines, cytokines and palmitate in the induction of insulin resistance are reviewed. The concentration of extracellular and intracellular Mg2+ in patients and the experimental effects of insulin and catecholamines on [Mg2+](i) in various tissues are described. The controversial effects of different serum Mg2+ concentrations and Mg2+ supplementation on plasma glucose and insulin concentration in studies with human subjects and the controversial results of epidemiological studies are reported. |Animals[MESH] |Diabetes Mellitus, Type 2/metabolism[MESH] |Humans[MESH] |Insulin Resistance/physiology[MESH] |Insulin Secretion[MESH] |Insulin/*metabolism[MESH] |Magnesium/*metabolism[MESH] |Obesity/metabolism[MESH]The biochemical function of Mg(2)+ in insulin secretion, insulin signa(epmc).pdf DeepDyve Pubget Overpricing