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10.1093/cvr/cvq089 http://scihub22266oqcxt.onion/10.1093/cvr/cvq089 20299332!ä!20299332 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\20299332.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cardiovasc+Res 2010 ; 87 (4): 713-22 Nephropedia Template TP {{tp|p=20299332|t=2010. Natural therapeutic magnesium lithospermate B potently protects the endothelium from hyperglycaemia-induced dysfunction |pdf=|usr=}}{{20299332}} gab.com Text Natural therapeutic magnesium lithospermate B potently protects the endothelium from hyperglycaemia-induced dysfunction JO: Cardiovasc Res http://www.kidney.de/pget.php?&tw=1&pmid=20299332 #FOAvip AIMS: We have investigated the effects of magnesium lithospermate B (MLB), the active compound of the Oriental herbal remedy, Salvia miltiorrhizae, on endothelial dysfunction associated with diabetes mellitus using cultured endothelial cells and an animal model of type 2 diabetes mellitus. METHODS AND RESULTS: The effect of MLB on vasodilatory function in Otsuka Long-Evans Tokushima Fatty (OLETF) rats was assessed. MLB treatment for 20 weeks starting at 12 weeks attenuated the decrease in endothelium-dependent vasodilation in OLETF rats. MLB treatment also increased serum nitrite level and reduced serum advanced glycation end products concentration. The effect of MLB was greater than an equivalent dose of alpha-lipoic acid (alphaLA), a popular antioxidant treatment. MLB rescued the inhibition of endothelial nitric oxide synthase (eNOS) activity and eNOS phosphorylation in endothelial cells cultured in hyperglycaemia. This effect was dependent on Akt phosphorylation and associated with decreased O-linked N-acetylglucosamine protein modification of eNOS. MLB also increased nuclear factor erythroid 2-related factor-2 (Nrf-2) activation in a phosphoinositide 3-kinase/Akt pathway dependent manner. MLB treatment induced the expression of the Nrf-2-regulated antioxidant enzyme, heme oxygenase-1. The antioxidant alphaLA could not produce this effect. Moreover, MLB decreased oxidative stress and endothelial cell apoptosis caused by hyperglycaemia. CONCLUSION: MLB is a naturally occurring, new generation antioxidant that activates eNOS and ameliorates endothelial dysfunction in diabetes by enhancing vasodilation in addition to reducing oxidative stress. The relative strong performance of MLB makes it an ideal candidate for further, expanded trials as a new generation of antioxidant to treat diabetes-related complications. Twit Text FOAVip Natural therapeutic magnesium lithospermate B potently protects the endothelium from hyperglycaemia-induced dysfunction ????Cardiovasc Res http://www.kidney.de/pget.php?&tw=1&pmid=20299332 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=20299332 #FOAvip English Wikipedia <ref>{{Cite pmid|20299332}}</ref> Natural therapeutic magnesium lithospermate B potently protects the endothelium from hyperglycaemia-induced dysfunction #MMPMID20299332 Kim SH; Kim SH; Choi M; Lee Y; Kim YO; Ahn DS; Kim YH; Kang ES; Lee EJ; Jung M; Cho JW; Williams DR; Lee HC Cardiovasc Res 2010[Sep]; 87 (4): 713-22 PMID20299332show ga AIMS: We have investigated the effects of magnesium lithospermate B (MLB), the active compound of the Oriental herbal remedy, Salvia miltiorrhizae, on endothelial dysfunction associated with diabetes mellitus using cultured endothelial cells and an animal model of type 2 diabetes mellitus. METHODS AND RESULTS: The effect of MLB on vasodilatory function in Otsuka Long-Evans Tokushima Fatty (OLETF) rats was assessed. MLB treatment for 20 weeks starting at 12 weeks attenuated the decrease in endothelium-dependent vasodilation in OLETF rats. MLB treatment also increased serum nitrite level and reduced serum advanced glycation end products concentration. The effect of MLB was greater than an equivalent dose of alpha-lipoic acid (alphaLA), a popular antioxidant treatment. MLB rescued the inhibition of endothelial nitric oxide synthase (eNOS) activity and eNOS phosphorylation in endothelial cells cultured in hyperglycaemia. This effect was dependent on Akt phosphorylation and associated with decreased O-linked N-acetylglucosamine protein modification of eNOS. MLB also increased nuclear factor erythroid 2-related factor-2 (Nrf-2) activation in a phosphoinositide 3-kinase/Akt pathway dependent manner. MLB treatment induced the expression of the Nrf-2-regulated antioxidant enzyme, heme oxygenase-1. The antioxidant alphaLA could not produce this effect. Moreover, MLB decreased oxidative stress and endothelial cell apoptosis caused by hyperglycaemia. CONCLUSION: MLB is a naturally occurring, new generation antioxidant that activates eNOS and ameliorates endothelial dysfunction in diabetes by enhancing vasodilation in addition to reducing oxidative stress. The relative strong performance of MLB makes it an ideal candidate for further, expanded trials as a new generation of antioxidant to treat diabetes-related complications. |Animals[MESH] |Antioxidants/*pharmacology[MESH] |Apoptosis/drug effects[MESH] |Cell Adhesion/drug effects[MESH] |Cells, Cultured[MESH] |Diabetes Mellitus, Type 2/complications/*drug therapy/metabolism/physiopathology[MESH] |Diabetic Angiopathies/*drug therapy/etiology/metabolism/physiopathology[MESH] |Disease Models, Animal[MESH] |Drugs, Chinese Herbal/*pharmacology[MESH] |Endothelium, Vascular/*drug effects/metabolism/pathology/physiopathology[MESH] |Glucose/*metabolism[MESH] |Glycation End Products, Advanced/blood[MESH] |Glycosylation[MESH] |Heme Oxygenase-1/metabolism[MESH] |Humans[MESH] |Leukocytes/drug effects[MESH] |NF-E2-Related Factor 2/metabolism[MESH] |Nitric Oxide Synthase Type III/metabolism[MESH] |Nitrites/blood[MESH] |Oxidative Stress/drug effects[MESH] |Phosphatidylinositol 3-Kinases/metabolism[MESH] |Phosphorylation[MESH] |Protein Processing, Post-Translational[MESH] |Proto-Oncogene Proteins c-akt/metabolism[MESH] |Rats[MESH] |Rats, Inbred OLETF[MESH] |Rats, Long-Evans[MESH] |Reactive Oxygen Species/metabolism[MESH] |Time Factors[MESH]Natural therapeutic magnesium lithospermate B potently protects the en(epmc).pdf DeepDyve Pubget Overpricing