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10.1016/j.vetimm.2010.03.004 http://scihub22266oqcxt.onion/10.1016/j.vetimm.2010.03.004 20356633!ä!20356633 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=20356633&cmd=llinks): Failed to open stream: HTTP request failed! 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A new strategy of immune evasion by influenza A virus: inhibition of monocyte differentiation into dendritic cells |pdf=|usr=}}{{20356633}} gab.com Text A new strategy of immune evasion by influenza A virus: inhibition of monocyte differentiation into dendritic cells JO: Vet Immunol Immunopathol http://www.kidney.de/pget.php?&tw=1&pmid=20356633 #FOAvip Dendritic cells (DC) play a versatile role in orchestrating immune responses against influenza virus. During inflammation or infection, monocytes preferentially differentiate to generate DCs. Here, we demonstrate that in vitro infection of monocytes with influenza virus impairs their development into DCs. Influenza infection of monocytes, pre-treated with GM-CSF and IL-4 for DC differentiation, was minimally productive and non-cytopathic. In spite of successful viral genome transcription, viral protein synthesis was restricted at an early stage. However, despite the limited replication, influenza infected monocytes failed to develop distinctive DC-like morphologies. Infected cells expressed reduced amounts of CD11c, CD172a, CD1w2 and CCR5. Antigen endocytosis by infected monocytes was also affected. Cytokine expression profiles were also modified which was conducive for arresting DC differentiation. At least limited viral replication was necessary for complete inhibition of differentiation. This identifies a new strategy by influenza virus to interfere with DC differentiation and evade virus specific immune responses. Twit Text FOAVip A new strategy of immune evasion by influenza A virus: inhibition of monocyte differentiation into dendritic cells ????Vet Immunol Immunopathol http://www.kidney.de/pget.php?&tw=1&pmid=20356633 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=20356633 #FOAvip English Wikipedia <ref>{{Cite pmid|20356633}}</ref> A new strategy of immune evasion by influenza A virus: inhibition of monocyte differentiation into dendritic cells #MMPMID20356633 Boliar S; Chambers TM Vet Immunol Immunopathol 2010[Aug]; 136 (3-4): 201-10 PMID20356633show ga Dendritic cells (DC) play a versatile role in orchestrating immune responses against influenza virus. During inflammation or infection, monocytes preferentially differentiate to generate DCs. Here, we demonstrate that in vitro infection of monocytes with influenza virus impairs their development into DCs. Influenza infection of monocytes, pre-treated with GM-CSF and IL-4 for DC differentiation, was minimally productive and non-cytopathic. In spite of successful viral genome transcription, viral protein synthesis was restricted at an early stage. However, despite the limited replication, influenza infected monocytes failed to develop distinctive DC-like morphologies. Infected cells expressed reduced amounts of CD11c, CD172a, CD1w2 and CCR5. Antigen endocytosis by infected monocytes was also affected. Cytokine expression profiles were also modified which was conducive for arresting DC differentiation. At least limited viral replication was necessary for complete inhibition of differentiation. This identifies a new strategy by influenza virus to interfere with DC differentiation and evade virus specific immune responses. |Animals[MESH] |Apoptosis/immunology[MESH] |Cell Differentiation/*immunology[MESH] |Dendritic Cells/cytology/immunology/virology[MESH] |Endocytosis/immunology[MESH] |Flow Cytometry/veterinary[MESH] |Granulocyte-Macrophage Colony-Stimulating Factor/immunology[MESH] |Horse Diseases/immunology/*virology[MESH] |Horses[MESH] |Immune Evasion/*immunology[MESH] |Immunophenotyping/veterinary[MESH] |Influenza A Virus, H7N7 Subtype/genetics/*immunology[MESH] |Interleukin-4/immunology[MESH] |Monocytes/cytology/immunology/*virology[MESH] |Orthomyxoviridae Infections/immunology/*veterinary/virology[MESH] |RNA, Viral/chemistry/genetics[MESH] |Reverse Transcriptase Polymerase Chain Reaction/veterinary[MESH] |Transcription, Genetic/immunology[MESH]A new strategy of immune evasion by influenza A virus: inhibition of m(epmc).pdf DeepDyve Pubget Overpricing