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10.1096/fj.10-158782 http://scihub22266oqcxt.onion/10.1096/fj.10-158782 20430792!2923361!20430792     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=20430792&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\20430792.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       FASEB+J 2010 ; 24 (9): 3341-50 Nephropedia Template TP {{tp|p=20430792|t=2010. Gene expression atlas for human embryogenesis |pdf=|usr=}}{{20430792}} gab.com Text Gene expression atlas for human embryogenesis JO: FASEB J http://www.kidney.de/pget.php?&tw=1&pmid=20430792 #FOAvip Human embryogenesis is believed to involve an integrated set of complex yet coordinated development of different organs and tissues mediated by the changes in the spatiotemporal expression of many genes. Here, we report a genome-wide expression analysis during wk 4-9 of human embryogenesis, a critical period when most organs develop. About half of all human genes are expressed, and 18.6% of the expressed genes were significantly regulated during this important period. We further identified >5000 regulated genes, most of which previously were not known to be associated with animal development. Our study fills an important gap in mammalian developmental studies by identifying functional pathways involved in this critical but previously not studied period. Our study also revealed that the genes involved here are distinct from those during early embryogenesis, which include three groups of maternal genes. Furthermore, we discovered that genes in a given developmental process are regulated coordinately. This led us to develop an easily searchable database of this entire collection of gene expression profiles, allowing for the identification new genes important for a particular developmental process/pathway and deducing the potential function of a novel gene. The validity of the predictions from the database was demonstrated with two examples through spatiotemporal analyses of the two novel genes. Such a database should serve as a highly valuable resource for the molecular analysis of human development and pathogenesis. Twit Text FOAVip Gene expression atlas for human embryogenesis ????FASEB J http://www.kidney.de/pget.php?&tw=1&pmid=20430792 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=20430792 #FOAvip English Wikipedia <ref>{{Cite pmid|20430792}}</ref> Gene expression atlas for human embryogenesis #MMPMID20430792 Yi H; Xue L; Guo MX; Ma J; Zeng Y; Wang W; Cai JY; Hu HM; Shu HB; Shi YB; Li WX FASEB J 2010[Sep]; 24 (9): 3341-50 PMID20430792show ga Human embryogenesis is believed to involve an integrated set of complex yet coordinated development of different organs and tissues mediated by the changes in the spatiotemporal expression of many genes. Here, we report a genome-wide expression analysis during wk 4-9 of human embryogenesis, a critical period when most organs develop. About half of all human genes are expressed, and 18.6% of the expressed genes were significantly regulated during this important period. We further identified >5000 regulated genes, most of which previously were not known to be associated with animal development. Our study fills an important gap in mammalian developmental studies by identifying functional pathways involved in this critical but previously not studied period. Our study also revealed that the genes involved here are distinct from those during early embryogenesis, which include three groups of maternal genes. Furthermore, we discovered that genes in a given developmental process are regulated coordinately. This led us to develop an easily searchable database of this entire collection of gene expression profiles, allowing for the identification new genes important for a particular developmental process/pathway and deducing the potential function of a novel gene. The validity of the predictions from the database was demonstrated with two examples through spatiotemporal analyses of the two novel genes. Such a database should serve as a highly valuable resource for the molecular analysis of human development and pathogenesis. |*Gene Expression Regulation, Developmental/genetics/physiology[MESH] |Embryonic Development/genetics/*physiology[MESH] |Gene Expression Profiling[MESH] |Humans[MESH] |Oligonucleotide Array Sequence Analysis[MESH]Gene expression atlas for human embryogenesis (epmc).pdf DeepDyve Pubget Overpricing