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A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1159/000315436 http://scihub22266oqcxt.onion/10.1159/000315436 20502037!�!20502037 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=20502037&cmd=llinks): Failed to open stream: HTTP request failed! 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Neutrophil gelatinase-associated lipocalin and hepcidin: what do they have in common and is there a potential interaction?|pdf=|usr=}}{{20502037}} gab.com Text Neutrophil gelatinase-associated lipocalin and hepcidin: what do they have in common and is there a potential interaction JO: Kidney Blood Press Res http://www.kidney.de/pget.php?&tw=1&pmid=20502037 #FOAvip Iron is the fourth most common element in the Earth's crust and is crucial for life. Over the last few years, our understanding of iron metabolism has dramatically increased due to the discovery of hepcidin, which is produced by hepatocytes and modulated in response to anemia, hypoxia and inflammation. It has been found that anemia upregulates lipocalin 2 (NGAL; neutrophil gelatinase-associated lipocalin) in the liver and serum. The aim of this review is to summarize the current knowledge dealing with a possible role of hepcidin and NGAL in iron metabolism and its regulation, particularly in kidney disease. Elevated NGAL a few days after insult is a possible preventive or protective mechanism limiting renal injury. NGAL is an innate antibacterial factor as well as hepcidin. NGAL binds siderophores, thereby preventing iron uptake by bacteria. Hepcidin, an antibacterial defensin, prevents iron absorption from the gut and iron release from macrophages, leading to hypoferremia and anemia. Both proteins sequester iron, but by different mechanisms. However, these proteins involved in iron metabolism do not seem to be independently related. Taking into account the antimicrobial moieties of NGAL, further studies are needed to address the role of NGAL in iron metabolism and inflammation in renal failure. Twit Text FOAVip Neutrophil gelatinase-associated lipocalin and hepcidin: what do they have in common and is there a potential interaction ????Kidney Blood Press Res http://www.kidney.de/pget.php?&tw=1&pmid=20502037 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=20502037 #FOAvip English Wikipedia <ref>{{Cite pmid|20502037}}</ref> Neutrophil gelatinase-associated lipocalin and hepcidin: what do they have in common and is there a potential interaction? #MMPMID20502037 Malyszko J; Tesar V; Macdougall IC Kidney Blood Press Res 2010[]; 33 (2): 157-65 PMID20502037show ga Iron is the fourth most common element in the Earth's crust and is crucial for life. Over the last few years, our understanding of iron metabolism has dramatically increased due to the discovery of hepcidin, which is produced by hepatocytes and modulated in response to anemia, hypoxia and inflammation. It has been found that anemia upregulates lipocalin 2 (NGAL; neutrophil gelatinase-associated lipocalin) in the liver and serum. The aim of this review is to summarize the current knowledge dealing with a possible role of hepcidin and NGAL in iron metabolism and its regulation, particularly in kidney disease. Elevated NGAL a few days after insult is a possible preventive or protective mechanism limiting renal injury. NGAL is an innate antibacterial factor as well as hepcidin. NGAL binds siderophores, thereby preventing iron uptake by bacteria. Hepcidin, an antibacterial defensin, prevents iron absorption from the gut and iron release from macrophages, leading to hypoferremia and anemia. Both proteins sequester iron, but by different mechanisms. However, these proteins involved in iron metabolism do not seem to be independently related. Taking into account the antimicrobial moieties of NGAL, further studies are needed to address the role of NGAL in iron metabolism and inflammation in renal failure. |Antimicrobial Cationic Peptides/*metabolism[MESH] |Gelatinases/*metabolism[MESH] |Hepcidins[MESH] |Humans[MESH] |Iron/metabolism[MESH] |Kidney Diseases/metabolism[MESH] |Lipocalins/*metabolism[MESH]Neutrophil gelatinase-associated lipocalin and hepcidin: what do they (epmc).pdf DeepDyve Pubget Overpricing