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10.1155/2010/359732 http://scihub22266oqcxt.onion/10.1155/2010/359732 20508722!2872759!20508722     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\20508722.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mediators+Inflamm 2010 ; 2010 (ä): 359732 Nephropedia Template TP {{tp|p=20508722|t=2010. Role of heme oxygenase in inflammation, insulin-signalling, diabetes and obesity |pdf=|usr=}}{{20508722}} gab.com Text Role of heme oxygenase in inflammation, insulin-signalling, diabetes and obesity JO: Mediators Inflamm http://www.kidney.de/pget.php?&tw=1&pmid=20508722 #FOAvip Diabetes and obesity are chronic conditions associated with elevated oxidative/inflammatory activities with a continuum of tissue insults leading to more severe cardiometabolic and renal complications including myocardial infarction and end-stage-renal damage. A common denominator of these chronic conditions is the enhanced the levels of cytokines like tumour necrosis factor-alpha (TNF-alpha), interleukin (IL-6), IL-1beta and resistin, which in turn activates the c-Jun-N-terminal kinase (JNK) and NF-kappaB pathways, creating a vicious cycle that exacerbates insulin resistance, type-2 diabetes and related complications. Emerging evidence indicates that heme oxygenase (HO) inducers are endowed with potent anti-diabetic and insulin sensitizing effects besides their ability to suppress immune/inflammatory response. Importantly, the HO system abates inflammation through several mechanisms including the suppression of macrophage-infiltration and abrogation of oxidative/inflammatory transcription factors like NF-kappaB, JNK and activating protein-1. This review highlights the mechanisms by which the HO system potentiates insulin signalling, with particular emphasis on HO-mediated suppression of oxidative and inflammatory insults. The HO system could be explored in the search for novel remedies against cardiometabolic diseases and their complications. Twit Text FOAVip Role of heme oxygenase in inflammation, insulin-signalling, diabetes and obesity ????Mediators Inflamm http://www.kidney.de/pget.php?&tw=1&pmid=20508722 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=20508722 #FOAvip English Wikipedia <ref>{{Cite pmid|20508722}}</ref> Role of heme oxygenase in inflammation, insulin-signalling, diabetes and obesity #MMPMID20508722 Ndisang JF Mediators Inflamm 2010[]; 2010 (ä): 359732 PMID20508722show ga Diabetes and obesity are chronic conditions associated with elevated oxidative/inflammatory activities with a continuum of tissue insults leading to more severe cardiometabolic and renal complications including myocardial infarction and end-stage-renal damage. A common denominator of these chronic conditions is the enhanced the levels of cytokines like tumour necrosis factor-alpha (TNF-alpha), interleukin (IL-6), IL-1beta and resistin, which in turn activates the c-Jun-N-terminal kinase (JNK) and NF-kappaB pathways, creating a vicious cycle that exacerbates insulin resistance, type-2 diabetes and related complications. Emerging evidence indicates that heme oxygenase (HO) inducers are endowed with potent anti-diabetic and insulin sensitizing effects besides their ability to suppress immune/inflammatory response. Importantly, the HO system abates inflammation through several mechanisms including the suppression of macrophage-infiltration and abrogation of oxidative/inflammatory transcription factors like NF-kappaB, JNK and activating protein-1. This review highlights the mechanisms by which the HO system potentiates insulin signalling, with particular emphasis on HO-mediated suppression of oxidative and inflammatory insults. The HO system could be explored in the search for novel remedies against cardiometabolic diseases and their complications. |*Signal Transduction[MESH] |Animals[MESH] |Diabetes Mellitus, Type 2/complications/*metabolism/physiopathology[MESH] |Heme Oxygenase (Decyclizing)/*metabolism[MESH] |Humans[MESH] |Inflammation/*metabolism[MESH] |Insulin Resistance/physiology[MESH] |Insulin/*metabolism[MESH] |Isoenzymes/*metabolism[MESH] |NF-kappa B/metabolism[MESH] |Obesity/complications/*metabolism/physiopathology[MESH]Role of heme oxygenase in inflammation, insulin-signalling, diabetes a(epmc).pdf DeepDyve Pubget Overpricing