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10.1097/MNH.0b013e32833c34ec http://scihub22266oqcxt.onion/10.1097/MNH.0b013e32833c34ec 20601877!4426959!20601877     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\20601877.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Curr+Opin+Nephrol+Hypertens 2010 ; 19 (5): 463-70 Nephropedia Template TP {{tp|p=20601877|t=2010. Regulation and function of potassium channels in aldosterone-sensitive distal nephron |pdf=|usr=}}{{20601877}} gab.com Text Regulation and function of potassium channels in aldosterone-sensitive distal nephron JO: Curr Opin Nephrol Hypertens http://www.kidney.de/pget.php?&tw=1&pmid=20601877 #FOAvip PURPOSE OF REVIEW: K channels in the aldosterone-sensitive distal nephron (ASDN) participate in generating cell membrane potential and in mediating K secretion. The aim of the review is to provide an overview of the recent development regarding physiological function of the K channels and the novel factors which modulate the K channels of the ASDN. RECENT FINDINGS: Genetic studies and transgenic mouse models have revealed the physiological function of basolateral K channels including inwardly rectifying K channel (Kir) and Ca-activated big-conductance K channels in mediating salt transport in the ASDN. A recent study shows that intersectin is required for mediating with-no-lysine kinase (WNK)-induced endocytosis. Moreover, a clathrin adaptor, autosomal recessive hypercholesterolemia (ARH), and an aging-suppression protein, Klothe, have been shown to regulate the endocytosis of renal outer medullary potassium (ROMK) channel. Also, serum-glucocorticoids-induced kinase I (SGK1) reversed the inhibitory effect of WNK4 on ROMK through the phosphorylation of WNK4. However, Src-family protein tyrosine kinase (SFK) abolished the effect of SGK1 on WNK4 and restored the WNK4-induced inhibition of ROMK. SUMMARY: Basolateral K channels including big-conductance K channel and Kir4.1/5.1 play an important role in regulating Na and Mg transport in the ASDN. Apical K channels are not only responsible for mediating K excretion but they are also involved in regulating transepithelial Mg absorption. New factors and mechanisms by which hormones and dietary K intake regulate apical K secretory channels expand the current knowledge regarding renal K handling. Twit Text FOAVip Regulation and function of potassium channels in aldosterone-sensitive distal nephron ????Curr Opin Nephrol Hypertens http://www.kidney.de/pget.php?&tw=1&pmid=20601877 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=20601877 #FOAvip English Wikipedia <ref>{{Cite pmid|20601877}}</ref> Regulation and function of potassium channels in aldosterone-sensitive distal nephron #MMPMID20601877 Wang WH; Yue P; Sun P; Lin DH Curr Opin Nephrol Hypertens 2010[Sep]; 19 (5): 463-70 PMID20601877show ga PURPOSE OF REVIEW: K channels in the aldosterone-sensitive distal nephron (ASDN) participate in generating cell membrane potential and in mediating K secretion. The aim of the review is to provide an overview of the recent development regarding physiological function of the K channels and the novel factors which modulate the K channels of the ASDN. RECENT FINDINGS: Genetic studies and transgenic mouse models have revealed the physiological function of basolateral K channels including inwardly rectifying K channel (Kir) and Ca-activated big-conductance K channels in mediating salt transport in the ASDN. A recent study shows that intersectin is required for mediating with-no-lysine kinase (WNK)-induced endocytosis. Moreover, a clathrin adaptor, autosomal recessive hypercholesterolemia (ARH), and an aging-suppression protein, Klothe, have been shown to regulate the endocytosis of renal outer medullary potassium (ROMK) channel. Also, serum-glucocorticoids-induced kinase I (SGK1) reversed the inhibitory effect of WNK4 on ROMK through the phosphorylation of WNK4. However, Src-family protein tyrosine kinase (SFK) abolished the effect of SGK1 on WNK4 and restored the WNK4-induced inhibition of ROMK. SUMMARY: Basolateral K channels including big-conductance K channel and Kir4.1/5.1 play an important role in regulating Na and Mg transport in the ASDN. Apical K channels are not only responsible for mediating K excretion but they are also involved in regulating transepithelial Mg absorption. New factors and mechanisms by which hormones and dietary K intake regulate apical K secretory channels expand the current knowledge regarding renal K handling. |Aldosterone/*pharmacology[MESH] |Animals[MESH] |Cyclic AMP-Dependent Protein Kinases/physiology[MESH] |Glucuronidase/physiology[MESH] |Humans[MESH] |Immediate-Early Proteins/physiology[MESH] |Intracellular Signaling Peptides and Proteins[MESH] |Klotho Proteins[MESH] |Magnesium/metabolism[MESH] |Minor Histocompatibility Antigens[MESH] |Nephrons/*metabolism[MESH] |Potassium Channels, Inwardly Rectifying/physiology[MESH] |Potassium Channels, Voltage-Gated/physiology[MESH] |Potassium Channels/*physiology[MESH] |Protein Kinase C/physiology[MESH] |Protein Serine-Threonine Kinases/physiology[MESH] |WNK Lysine-Deficient Protein Kinase 1[MESH]Regulation and function of potassium channels in aldosterone-sensitive(epmc).pdf DeepDyve Pubget Overpricing